公开(公告)号：US11013802B2

公开(公告)日：2021-05-25

申请号：US15834290

申请日：2017-12-07

申请人： Agenus Inc. ,  Ludwig Institute for Cancer Research Ltd ,  Memorial Sloan Kettering Cancer Center

发明人： Marc van Dijk ,  Cornelia Anne Mundt ,  Gerd Ritter ,  David Schaer ,  Jedd David Wolchok ,  Taha Merghoub ,  Nicholas Stuart Wilson ,  David Adam Savitsky ,  Mark Arthur Findeis ,  Dennis John Underwood ,  Jean-Marie Cuillerot ,  Igor Proscurshim ,  Olga Shebanova

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P11/00 ,  A61P35/04 ,  A61K39/00

摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

公开(公告)号：US10912831B1

公开(公告)日：2021-02-09

申请号：US17030650

申请日：2020-09-24

申请人： Agenus Inc. ,  Ludwig Institute for Cancer Research Ltd ,  Memorial Sloan Kettering Cancer Center

发明人： Marc van Dijk ,  Cornelia Anne Mundt ,  Gerd Ritter ,  David Schaer ,  Jedd David Wolchok ,  Taha Merghoub ,  Nicholas Stuart Wilson ,  David Adam Savitsky ,  Mark Arthur Findeis ,  Dennis John Underwood ,  Jean-Marie Cuillerot ,  Igor Proscurshim ,  Olga Shebanova

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P11/00 ,  A61P35/04 ,  A61K39/00

摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

公开(公告)号：US20180185481A1

公开(公告)日：2018-07-05

申请号：US15834290

申请日：2017-12-07

申请人： Agenus Inc. ,  Ludwig Institute for Cancer Research Ltd ,  Memorial Sloan Kettering Cancer Center

发明人： Marc van Dijk ,  Cornelia Anne Mundt ,  Gerd Ritter ,  David Schaer ,  Jedd David Wolchok ,  Taha Merghoub ,  Nicholas Stuart Wilson ,  David Adam Savitsky ,  Mark Arthur Findeis ,  Dennis John Underwood ,  Jean-Marie Cuillerot ,  Igor Proscurshim ,  Olga Shebanova

IPC分类号： A61K39/395 ,  A61P11/00 ,  A61P35/04

摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

公开(公告)号：US20210205451A1

公开(公告)日：2021-07-08

申请号：US17121229

申请日：2020-12-14

申请人： Agenus Inc. ,  Ludwig Institute for Cancer Research Ltd ,  Memorial Sloan Kettering Cancer Center

发明人： Marc van Dijk ,  Cornelia Anne Mundt ,  Gerd Ritter ,  David Schaer ,  Jedd David Wolchok ,  Taha Merghoub ,  Nicholas Stuart Wilson ,  David Adam Savitsky ,  Mark Arthur Findeis ,  Dennis John Underwood ,  Jean-Marie Cuillerot ,  Igor Proscurshim ,  Olga Shebanova

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P11/00 ,  A61P35/04

摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

公开(公告)号：US11638755B2

公开(公告)日：2023-05-02

申请号：US17121229

申请日：2020-12-14

申请人： Agenus Inc. ,  Ludwig Institute for Cancer Research Ltd. ,  Memorial Sloan Kettering Cancer Center

发明人： Marc van Dijk ,  Cornelia Anne Mundt ,  Gerd Ritter ,  David Schaer ,  Jedd David Wolchok ,  Taha Merghoub ,  Nicholas Stuart Wilson ,  David Adam Savitsky ,  Mark Arthur Findeis ,  Dennis John Underwood ,  Jean-Marie Cuillerot ,  Igor Proscurshim ,  Olga Shebanova

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P35/04 ,  A61P11/00 ,  A61K39/00

摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

公开(公告)号：US20210023214A1

公开(公告)日：2021-01-28

申请号：US17030650

申请日：2020-09-24

申请人： Agenus Inc. ,  Ludwig Institute for Cancer Research Ltd ,  Memorial Sloan Kettering Cancer Center

发明人： Marc van Dijk ,  Cornelia Anne Mundt ,  Gerd Ritter ,  David Schaer ,  Jedd David Wolchok ,  Taha Merghoub ,  Nicholas Stuart Wilson ,  David Adam Savitsky ,  Mark Arthur Findeis ,  Dennis John Underwood ,  Jean-Marie Cuillerot ,  Igor Proscurshim ,  Olga Shebanova

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P11/00 ,  A61P35/04

摘要： The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.