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公开(公告)号:US20230002816A1
公开(公告)日:2023-01-05
申请号:US17885188
申请日:2022-08-10
IPC分类号: C12Q1/6841 , G01N33/58 , C07D311/82 , C07D311/90 , C07D493/10 , C12N9/08 , C12N9/96 , C12Q1/28
摘要: Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as a rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color.
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公开(公告)号:US11466314B2
公开(公告)日:2022-10-11
申请号:US16688076
申请日:2019-11-19
IPC分类号: C12Q1/68 , C07D311/82 , C07D311/90 , C12Q1/6841 , G01N33/58 , C07D493/10 , C12N9/08 , C12N9/96 , C12Q1/28
摘要: Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as a rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color.
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公开(公告)号:US20200292535A1
公开(公告)日:2020-09-17
申请号:US16838623
申请日:2020-04-02
发明人: Jesper Lohse , Kristian Jensen , Rikke Malene Krusenst Jerna-Hafstrøm , Kirsten Damgaard Hoff , Lars Christian Jacobsen
摘要: The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunosiained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions tire useful for evaluation of targets that are biomarkers of diseases in medical diagnostic.
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公开(公告)号:US20200157613A1
公开(公告)日:2020-05-21
申请号:US16688076
申请日:2019-11-19
IPC分类号: C12Q1/6841 , C12Q1/28 , C12N9/96 , C12N9/08 , C07D493/10 , C07D311/90 , C07D311/82 , G01N33/58
摘要: Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as a rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color.
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