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公开(公告)号：US11505826B2
公开(公告)日：2022-11-22
申请号：US15648240
申请日：2017-07-12
IPC分类号： C12Q1/68 , C12Q1/6874 , C12Q1/6806
摘要： The present disclosure is directed to a single-end sequencing method for improved detection of genomic rearrangements such as deletions, insertions, inversions, and translocations that are present in a polynucleotide. A first priming event allows for sequencing of a target sequence, and a second priming event on an adapter allows for identification of the sequences amplified and tagged by selective amplification. The combination of priming events in the same direction facilitates read alignment and the identification of any genomic rearrangements.
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公开(公告)号：US20220364169A1
公开(公告)日：2022-11-17
申请号：US17875153
申请日：2022-07-27
IPC分类号： C12Q1/6874 , C12Q1/6806
摘要： The present disclosure is directed to a single-end sequencing method for improved detection of genomic rearrangements such as deletions, insertions, inversions, and translocations that are present in a polynucleotide. A first priming event allows for sequencing of a target sequence, and a second priming event on an adapter allows for identification of the sequences amplified and tagged by selective amplification. The combination of priming events in the same direction facilitates read alignment and the identification of any genomic rearrangements.
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公开(公告)号：US20190017113A1
公开(公告)日：2019-01-17
申请号：US15648240
申请日：2017-07-12
IPC分类号： C12Q1/68
摘要： The present disclosure is directed to a single-end sequencing method for improved detection of genomic rearrangements such as deletions, insertions, inversions, and translocations that are present in a polynucleotide. A first priming event allows for sequencing of a target sequence, and a second priming event on an adapter allows for identification of the sequences amplified and tagged by selective amplification. The combination of priming events in the same direction facilitates read alignment and the identification of any genomic rearrangements.
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