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公开(公告)号：US11464775B2
公开(公告)日：2022-10-11
申请号：US16639086
申请日：2018-08-15
发明人： Giovanni Cianchetta , Charles Kung , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： A61K31/5025 , A61K31/506 , A61K31/519 , C07D241/36 , C07D513/14 , A61K45/06
摘要： Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.
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公开(公告)号：US20200207785A1
公开(公告)日：2020-07-02
申请号：US16639081
申请日：2018-08-15
发明人： Giovanni Cianchetta , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： C07D513/14 , C07D241/36
摘要： Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein
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公开(公告)号：US10028961B2
公开(公告)日：2018-07-24
申请号：US15093345
申请日：2016-04-07
发明人： Zenon D. Konteatis , Janeta Popovici-Muller , Jeremy M. Travins , Robert Zahler , Zhenwei Cai , Ding Zhou
IPC分类号： C07D401/04 , C07D403/04 , A61K31/506 , A61P35/00 , A61K31/53 , C07D417/04 , A61K45/06 , C07D251/18 , C07D401/14 , C07D405/14 , C07D405/12 , C07D413/04 , C07D417/14
CPC分类号： A61K31/53 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
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公开(公告)号：US09850277B2
公开(公告)日：2017-12-26
申请号：US15279146
申请日：2016-09-28
发明人： Janeta Popovici-Muller , Rene M. Lemieux , Jeremy Travins , Zhenwei Cai , Dawei Cui , Ding Zhou
IPC分类号： C07D207/26 , C07D401/04 , C07D403/04 , C07K5/065 , C07D205/08 , A61K38/05 , A61K45/06 , C07D401/14 , C07D413/04 , C07D417/04 , A61K38/00 , C07K5/06
CPC分类号： C07K5/06078 , A61K38/005 , A61K38/05 , A61K45/06 , C07D205/08 , C07D207/26 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D417/04 , C07K5/06191
摘要： Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
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公开(公告)号：US10946023B2
公开(公告)日：2021-03-16
申请号：US16167725
申请日：2018-10-23
发明人： Zenon D. Konteatis , Janeta Popovici-Muller , Jeremy Travins , Robert Zahler , Zhenwei Cai , Ding Zhou
IPC分类号： C07D251/48 , C07D251/10 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/53 , A61K45/06 , C07D251/18 , A61K31/506 , A61K31/5377
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
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公开(公告)号：US20160220572A1
公开(公告)日：2016-08-04
申请号：US15093345
申请日：2016-04-07
发明人： Zenon D. Konteatis , Janeta Popovici-Muller , Jeremy M. Travins , Robert Zahler , Zhenwei Cai , Ding Zhou
IPC分类号： A61K31/53 , C07D401/04 , C07D251/18 , C07D405/14 , A61K31/506 , C07D405/12 , C07D403/04 , C07D417/04 , C07D413/04 , C07D417/14 , A61K45/06 , C07D401/14
CPC分类号： A61K31/53 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
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公开(公告)号：US20160130298A1
公开(公告)日：2016-05-12
申请号：US14988661
申请日：2016-01-05
发明人： Rene M. Lemieux , Janeta Popovici-Muller , Jeremy Travins , Zhenwei Cai , Dawei Cui , Ding Zhou
CPC分类号： C07K5/06078 , A61K38/005 , A61K38/05 , A61K45/06 , C07D205/08 , C07D207/26 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D417/04 , C07K5/06191
摘要： Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
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公开(公告)号：US11872225B2
公开(公告)日：2024-01-16
申请号：US17586777
申请日：2022-01-27
发明人： Giovanni Cianchetta , Charles Kung , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： C07D513/14 , A61K31/5025 , A61K31/506 , A61K31/519 , C07D241/36 , A61K45/06
CPC分类号： A61K31/5025 , A61K31/506 , A61K31/519 , C07D241/36 , C07D513/14 , A61K45/06
摘要： Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I):
wherein R1, R2, L1, and L2 are as defined herein.-
公开(公告)号：US11040036B2
公开(公告)日：2021-06-22
申请号：US16952257
申请日：2020-11-19
发明人： Giovanni Cianchetta , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： A61K31/5025 , A61K31/506 , A61K31/519 , A61K45/06 , C07D241/36 , C07D513/14
摘要： Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein.
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公开(公告)号：US20200206225A1
公开(公告)日：2020-07-02
申请号：US16639086
申请日：2018-08-15
发明人： Giovanni Cianchetta , Charles Kung , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： A61K31/5025 , A61K31/519 , A61K31/506
摘要： Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.
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