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1.发明申请Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents 审中-公开用作抗惊厥剂的新型苯并稠合的杂芳基磺酰胺衍生物公开(公告)号：US20060276528A1
公开(公告)日：2006-12-07
申请号：US11359626
申请日：2006-02-22
IPC分类号： A61K31/404 , A61K31/381 , A61K31/4025 , A61K31/343 , C07D333/02
CPC分类号： C07D307/81 , C07D209/14 , C07D333/58 , C07D409/12
摘要： The present invention is directed to novel benzo-fused heteroaryl sulfamide derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders. The present invention is further directed to a crystalline form of N-(benzo[b]thien-3-ylmethyl)-sulfamide and a process for its preparation.
摘要翻译： 本发明涉及新颖的苯并稠合杂芳基磺酰胺衍生物，含有它们的药物组合物及其在治疗癫痫和相关疾病中的用途。 本发明还涉及N-（苯并[b]噻吩-3-基甲基） - 磺酰胺的结晶形式及其制备方法。
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公开(公告)号：US20060058373A1
公开(公告)日：2006-03-16
申请号：US11265670
申请日：2005-11-02
IPC分类号： A61K31/255 , C07C311/45 , A61K31/695
摘要： The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy. The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.
摘要翻译： 本发明涉及新的式（I）化合物，
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公开(公告)号：US20070293476A1
公开(公告)日：2007-12-20
申请号：US11750579
申请日：2007-05-18
IPC分类号： A61K31/55 , A61K31/454 , A61K31/405 , A61K31/4025 , A61K31/381 , A61K31/343
CPC分类号： A61K45/06 , A61K31/381
摘要： The present invention is directed to a method for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-heteroaryl sulfamide derivative as described herein and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.
摘要翻译： 本发明涉及治疗癫痫和相关病症的方法，其包括向有需要的受试者施用治疗有效量的如本文所述的苯并杂芳基磺酰胺衍生物和治疗有效量的一种 或更多抗惊厥药和/或抗癫痫剂。
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4.发明申请Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders 有权用于治疗癫痫和相关疾病的新型氨基磺酸盐和磺酰胺衍生物公开(公告)号：US20060041008A1
公开(公告)日：2006-02-23
申请号：US11154443
申请日：2005-06-16
申请人： David McComsey , Michael Parker , Allen Reitz , Bruce Maryanoff
发明人： David McComsey , Michael Parker , Allen Reitz , Bruce Maryanoff
IPC分类号： A61K31/335 , A61K31/36
CPC分类号： C07D319/20 , C07D311/58 , C07D317/58 , C07D321/10
摘要： The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.
摘要翻译： 本发明涉及新型磺酰胺和氨基磺酸酯衍生物，含有它们的药物组合物及其在治疗癫痫和相关疾病中的用途。
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![CRYSTALLINE FORMS OF N-(BENZO[B]THIEN-3-YLMETHYL)-SULFAMIDE](/abs-image/US/2007/10/04/US20070232685A1/abs.jpg.150x150.jpg)
5.发明申请公开(公告)号：US20070232685A1
公开(公告)日：2007-10-04
申请号：US11677717
申请日：2007-02-22
申请人： Nagy Fawzy , Michael Parker , Allen Reitz , Bruce Maryanoff
发明人： Nagy Fawzy , Michael Parker , Allen Reitz , Bruce Maryanoff
IPC分类号： A61K31/381 , C07D333/56
CPC分类号： C07D333/58
摘要： The present invention is directed to anhydrous and solvated, crystalline forms of N-(benzo[b]thien-3-ylmethyl)-sulfamide, pharmaceutical compositions containing said crystalline forms and their use in the treatment epilepsy and related disorders.
摘要翻译： 本发明涉及N-（苯并[b]噻吩-3-基甲基） - 磺酰胺的无水和溶剂化结晶形式，含有所述结晶形式的药物组合物及其在治疗癫痫和相关疾病中的用途。
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6.发明申请Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents 审中-公开用作抗惊厥剂的新型苯并稠合的杂芳基磺酰胺衍生物公开(公告)号：US20060047001A1
公开(公告)日：2006-03-02
申请号：US11209122
申请日：2005-08-22
申请人： Michael Parker , Allen Reitz , Bruce Maryanoff
发明人： Michael Parker , Allen Reitz , Bruce Maryanoff
IPC分类号： A61K31/405 , A61K31/381 , A61K31/343 , A61K31/16
CPC分类号： C07C307/06 , C07D209/14 , C07D307/81 , C07D333/20 , C07D333/58 , C07D409/12
摘要： The present invention is directed to novel benzo-fused heteroaryl sulfamide derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.
摘要翻译： 本发明涉及新颖的苯并稠合杂芳基磺酰胺衍生物，含有它们的药物组合物及其在治疗癫痫和相关疾病中的用途。
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7.发明申请Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders 审中-公开用于治疗癫痫和相关疾病的新型氨基磺酸盐和磺酰胺衍生物公开(公告)号：US20050282887A1
公开(公告)日：2005-12-22
申请号：US11154386
申请日：2005-06-16
申请人： David McComsey , Michael Parker , Allen Reitz , Bruce Maryanoff
发明人： David McComsey , Michael Parker , Allen Reitz , Bruce Maryanoff
IPC分类号： A61K31/353 , A61K31/357 , A61K31/36 , C07D311/58 , C07D317/58 , C07D319/20 , C07D321/08
CPC分类号： C07D321/08 , C07D311/58 , C07D317/58 , C07D319/20
摘要： The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.
摘要翻译： 本发明涉及新型磺酰胺和氨基磺酸酯衍生物，含有它们的药物组合物及其在治疗癫痫和相关疾病中的用途。
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公开(公告)号：US20070293440A1
公开(公告)日：2007-12-20
申请号：US11750600
申请日：2007-05-18
IPC分类号： A61K31/7008 , A61K31/5513 , A61K31/55 , A61K31/353 , A61K31/343 , A61K31/515 , A61K31/335 , A61K31/35 , A61K31/36 , A61K31/198
CPC分类号： A61K31/337 , A61K31/18 , A61K45/06 , C07D311/58 , C07D317/46 , C07D317/70 , C07D319/20 , C07D319/22 , C07D321/10 , A61K2300/00
摘要： The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.
摘要翻译： 本发明涉及用于治疗癫痫和相关病症的共同治疗，其包括向有需要的受试者施用治疗有效量的苯并稠合的杂环磺酰胺衍生物和治疗有效量的一种或多种 更多的抗惊厥药和/或抗癫痫剂。
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![NOVEL 2-AMINO-3,4-DIHYDRO-PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE)](/abs-image/US/2007/11/08/US20070259898A1/abs.jpg.150x150.jpg)
9.发明申请NOVEL 2-AMINO-3,4-DIHYDRO-PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE) 有权新型2-氨基-3,4-二氢吡啶并[3,4-D]吡啶衍生物作为β-分泌酶（BACE）的抑制剂有用公开(公告)号：US20070259898A1
公开(公告)日：2007-11-08
申请号：US11552792
申请日：2006-10-25
申请人： Ellen Baxter , Christopher Creighton , Yifang Huang , Chi Luo , Michael Parker , Allen Reitz , Charles Reynolds , Tina Ross , Eric Strobel , Brett Tounge
发明人： Ellen Baxter , Christopher Creighton , Yifang Huang , Chi Luo , Michael Parker , Allen Reitz , Charles Reynolds , Tina Ross , Eric Strobel , Brett Tounge
IPC分类号： A61K31/519 , A61P25/28 , C07D211/72 , C07D471/04
CPC分类号： C07D213/73 , C07D471/04
摘要： The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
摘要翻译： 本发明涉及新的2-氨基-3,4-二氢 - 吡啶并[3,4-d]嘧啶衍生物，含有它们的药物组合物及其在治疗阿尔茨海默病（AD）和相关疾病中的用途。 本发明的化合物是β-分泌酶的抑制剂，也称为β-位点切割酶和BACE，BACE1，Asp2和memapsin2。
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10.发明申请公开(公告)号：US20070004715A1
公开(公告)日：2007-01-04
申请号：US11443928
申请日：2006-05-31
申请人： Yifang Huang , Michael Parker , Allen Reitz
发明人： Yifang Huang , Michael Parker , Allen Reitz
IPC分类号： A61K31/538 , C07D491/04
CPC分类号： C07D491/04
摘要： The present invention is directed to novel spiro-quinuclidinyl derivatives, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.
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