专利检索 ap:("Ahmed Kamal" OR "Gollapalli B. Ramesh Khanna" OR "Krishnaji Tadiparthi" OR "Ramu Rondla") AND inv:"Gollapalli B. Ramesh Khanna" 第 1 页

1.

发明授权
Enantioconvergent chemoenzymatic synthesis of (R)-γ-amino-β-hydroxybutyric acid ((R)-GABOB) 有权
标题翻译：（R） - 氨基-β-羟基丁酸（（R）-GABOB）的光化学转化化学酶合成

公开(公告)号：US07374926B2

公开(公告)日：2008-05-20

申请号：US11022275

申请日：2004-12-23

申请人： Ahmed Kamal , Gollapalli B. Ramesh Khanna , Krishnaji Tadiparthi , Ramu Rondla

发明人： Ahmed Kamal , Gollapalli B. Ramesh Khanna , Krishnaji Tadiparthi , Ramu Rondla

IPC分类号： C12P41/00 , C12P13/00 , C12P7/00 , C12P7/04 , C12P7/52

CPC分类号： C12P13/005 , C12P13/002 , C12P41/004

摘要： The present invention particularly relates to a chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile key intermediates for the preparation of (R)-GABOB by lipase mediated kinetic resolution of its racemates and their effective application in the enantioconvergent synthesis of (R)-GABOB.

摘要翻译： 本发明特别涉及用于通过脂肪酶介导的其外消旋物的动力学拆分制备（R）-GABOB的3-羟基-4-三苯甲氧基丁腈关键中间体的两种对映体的立体选择性制备的化学酶学方法及其在（R）-GABOB的对映异构体合成。