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1.发明申请Chemoenzymatic Process for the Stereoselective Preparation of (R)-Gamma-Amino-Beta-Hydroxybutyric Acid [(R)-GABOB) and (R)-Carnitine 有权（R） - 氨基-β-羟基丁酸[（R）-GABOB）和（R） - 卡尼汀的立体选择性制备的化学方法公开(公告)号：US20090233337A1
公开(公告)日：2009-09-17
申请号：US11911643
申请日：2005-11-29
IPC分类号： C12P13/00
CPC分类号： C12P13/002 , C07C227/32 , C12P13/005 , C12P13/007 , C12P41/004 , C07C229/22
摘要： The present invention provides a chemoenzymatic process for the preparation of (R)-GABOB and (R)-carnitine employing lipase-mediated resolution of 3-hydroxy-4-tosyloxybutanenitrile as the key step. The drawing accompanying this specification represents the preparation of racemic 3-hydroxy-4-tosyloxybutanenitrile, its lipase-mediated kinetic resolution and its successful application in the preparation of (R)-GABOB and (R)-carnitine.
摘要翻译： 本发明提供了使用脂肪酶介导的3-羟基-4-甲苯氧基丁腈的拆分作为关键步骤制备（R）-GABOB和（R） - 肉碱的化学酶法。 本说明书附图表示外消旋3-羟基-4-甲苯氧基丁腈的制备，其脂肪酶介导的动力学拆分及其在制备（R）-GABOB和（R） - 肉碱中的成功应用。
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2.发明授权Chemoenzymatic process for the stereoselective preparation of (R)-γ-amino-β-hydroxybutyric acid or (R)-carnitine from 3,4-dihydroxybutanenitrile 有权（R）-γ-氨基 - （b） - 羟基丁酸或（R） - 肉碱从3,4-二羟基丁腈立体选择性制备的化学酶法公开(公告)号：US07816119B2
公开(公告)日：2010-10-19
申请号：US11911643
申请日：2005-11-29
IPC分类号： C12P41/00
CPC分类号： C12P13/002 , C07C227/32 , C12P13/005 , C12P13/007 , C12P41/004 , C07C229/22
摘要： The present invention provides a chemoenzymatic process for the preparation of (R)-GABOB and (R)-carnitine employing lipase-mediated resolution of 3-hydroxy-4-tosyloxybutanenitrile as the key step. The drawing accompanying this specification represents the preparation of racemic 3-hydroxy-4-tosyloxybutanenitrile, its lipase-mediated kinetic resolution and its successful application in the preparation of (R)-GABOB and (R)-carnitine.
摘要翻译： 本发明提供了使用脂肪酶介导的3-羟基-4-甲苯氧基丁腈的拆分作为关键步骤制备（R）-GABOB和（R） - 肉碱的化学酶法。 本说明书附图表示外消旋3-羟基-4-甲苯氧基丁腈的制备，其脂肪酶介导的动力学拆分及其在制备（R）-GABOB和（R） - 肉碱中的成功应用。
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![Bis-pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates and a process for the preparation thereof](/abs-image/US/2008/12/16/US07465724B2/abs.jpg.150x150.jpg)
3.发明授权Bis-pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates and a process for the preparation thereof 有权双吡咯并[2,1-c] [1,4]苯并二氮杂蒽醌共轭物及其制备方法公开(公告)号：US07465724B2
公开(公告)日：2008-12-16
申请号：US11705660
申请日：2007-02-12
IPC分类号： C07D405/14 , A61K31/551
CPC分类号： C07D519/00
摘要： The present invention provides novel bis-pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates of general formula V, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of novel bis-pyrrolo[2,1 -c][1,4]benzodiazepine-anthraquinone conjugates of general formula V. wherein n=3, 4, or 5.
摘要翻译： 本发明提供通用V的新颖的双吡咯并[2,1-c] [1,4]苯并二氮杂 - 蒽醌共轭物，其可用作抗人肿瘤细胞系的潜在抗肿瘤剂。 本发明还提供了制备通式Ⅴ的新的双吡咯并[2,1-c] [1,4]苯并二氮杂-蒽醌共轭物的方法，其中n = 3,4或5。
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