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1.发明申请NOVEL BACTERIAL STRAIN OF ACHROMOBACTER SP. MTCC 5605 AND A HIGHLY ENANTIOSELECTIVE EPOXIDE HYDROLASE ISOLATED THEREFROM 有权ACHROMOBACTER SP的新型细菌菌株 MTCC 5605和分离的高选择性环氧化物水解剂公开(公告)号：US20140011224A1
公开(公告)日：2014-01-09
申请号：US14000730
申请日：2012-08-27
CPC分类号： C12N9/14 , C12P7/18 , C12P41/001 , C12R1/025 , C12Y303/02003
摘要： The present invention relates to a novel epoxide hydrolase enzyme which aims to achieve a high degree of resolution towards a broader range of substrates with high enantioselectivity and yields with minimal product inhibition. The invention further relates to a new bacterial strain Achromobacter sp. MTCC 5605 isolated from a petroleum-contaminated sludge sample, capable of producing the said enzyme. It is notable that the enzyme can be used as whole bacterial cell preparation, which allows continuous hydrolysis of substrates at even higher concentration and have an advantage of being recycled. The invention further relates to a process for the hydrolysis of different aryl epoxides which are potential synthons of intermediates for the synthesis of chiral amino alcohols and bioactive compounds like β-blockers.
摘要翻译： 本发明涉及一种新的环氧化物水解酶，其目的是为具有高对映选择性的较宽范围的底物获得高度的分辨率，并以最小的产物抑制率得到产率。 本发明还涉及一种新的细菌菌株Achromobacter sp。 从能够产生所述酶的经石油污染的污泥样品中分离出的MTCC 5605。 值得注意的是，该酶可以用作整个细菌细胞制剂，其允许以更高浓度连续水解底物并且具有被回收的优点。 本发明还涉及水解不同芳基环氧化物的方法，它们是合成手性氨基醇和生物活性化合物如β-阻滞剂的中间体的潜在合成子。
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2.发明授权Isolated bacterial strain of Achromobacter sp. MTCC 5605 and a highly enantioselective epoxide hydrolase isolated therefrom 有权无色杆菌的分离菌株 MTCC 5605和从其分离的高度对映选择性的环氧化物水解酶公开(公告)号：US09150840B2
公开(公告)日：2015-10-06
申请号：US14000730
申请日：2012-08-27
CPC分类号： C12N9/14 , C12P7/18 , C12P41/001 , C12R1/025 , C12Y303/02003
摘要： The present invention relates to a novel epoxide hydrolase enzyme which aims to achieve a high degree of resolution towards a broader range of substrates with high enantioselectivity and yields with minimal product inhibition. The invention further relates to a new bacterial strain Achromobacter sp. MTCC 5605 isolated from a petroleum-contaminated sludge sample, capable of producing the said enzyme. It is notable that the enzyme can be used as whole bacterial cell preparation, which allows continuous hydrolysis of substrates at even higher concentration and have an advantage of being recycled. The invention further relates to a process for the hydrolysis of different aryl epoxides which are potential synthons of intermediates for the synthesis of chiral amino alcohols and bioactive compounds like β-blockers.
摘要翻译： 本发明涉及一种新的环氧化物水解酶，其目的是为具有高对映选择性的较宽范围的底物获得高度的分辨率，并以最小的产物抑制率得到产率。 本发明还涉及一种新的细菌菌株Achromobacter sp。 从能够产生所述酶的经石油污染的污泥样品中分离出的MTCC 5605。 值得注意的是，该酶可以用作整个细菌细胞制剂，其允许以更高浓度连续水解底物并且具有被回收的优点。 本发明还涉及用于水解不同芳基环氧化物的方法，它们是用于合成手性氨基醇和生物活性化合物（例如） - 阻滞剂的中间体的潜在合成子。
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