公开(公告)号：US20090286974A1

公开(公告)日：2009-11-19

申请号：US11990977

申请日：2006-08-24

申请人： Akiko Itai ,  Susumu Muto ,  RYuko Tokuyama ,  Hiroshi Fukasawa ,  Takafumi Ohara ,  Terukazu Kato

发明人： Akiko Itai ,  Susumu Muto ,  RYuko Tokuyama ,  Hiroshi Fukasawa ,  Takafumi Ohara ,  Terukazu Kato

IPC分类号： C07D417/04 ,  C07D403/04

CPC分类号： C07D211/22 ,  C07D211/58 ,  C07D241/04 ,  C07D241/44 ,  C07D277/82 ,  C07D401/04 ,  C07D403/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12

摘要： A compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein Ring Q is optionally substituted monocyclic aryl, optionally substituted monocyclic heteroaryl, optionally substituted fused aryl or optionally substituted fused heteroaryl, Y1 is a bond or —NR6— or the like, Ring A is optionally substituted nonaromatic heterocyclediyl, a group of the formula: -Y2Z1- is a group of the formula: R7 are each independently hydrogen, optionally substituted lower alkyl or the like, R8 and R9 are each independently hydrogen or optionally substituted lower alkyl, n is an integer between 1 and 3, Z1 is a bond, —O—, —S— or —NR9—, Ring B is optionally substituted aromatic carbocyclediyl or optionally substituted aromatic heterocyclediyl, Y3 is a bond, optionally substituted lower alkylene optionally intervened by —O—, optionally substituted lower alkenylene or the like, and Z2 is COOR3 or the like.

摘要翻译： 式（I）的化合物：其药学上可接受的盐或溶剂化物，其中环Q是任选取代的单环芳基，任选取代的单环杂芳基，任选取代的稠合芳基或任选取代的稠合杂芳基，Y1是键或-NR 6 - 或 环A是任选取代的非芳族杂环二基，下式基团：-Y 2 Z 1 - 是下式​​的基团：R 7各自独立地为氢，任选取代的低级烷基等，R 8和R 9各自独立地为氢或任选地 取代的低级烷基，n是1和3之间的整数，Z 1是键，-O-，-S-或-NR 9 - ，环B是任选取代的芳族碳环二基或任选取代的芳族杂环二基，Y 3是一个键， 任选地被-O-，任选取代的低级亚烯基等所介导的低级亚烷基，Z 2是COOR 3等。