公开(公告)号：US5202324A

公开(公告)日：1993-04-13

申请号：US472804

申请日：1990-01-31

申请人： Akio Miyake ,  Masaaki Kuwahara ,  Hisashi Kuriki

发明人： Akio Miyake ,  Masaaki Kuwahara ,  Hisashi Kuriki

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The imidazo[1,2-b]pyridazine compounds of the formula: ##STR1## wherein R.sub.1 is a hydrogen or halogen atom, or a lower alkyl group optionally having substituent(s), R.sub.2 and R.sub.3 are, independently, a hydrogen atom, a lower alkyl group optionally having substituent(s), a cycloalkyl group or a phenyl group optionally having substituent(s) or R.sub.2 and R.sub.3 together with the adjacent nitrogen atom to which they bond may form a heterocyclic ring optionally having substituent(s), X is an oxygen atom or S(O).sub.n (n=0 to 2), Alk is a straight or branched chain alkylene group containing 1-10 carbon atoms and optionally having substituent(s), or their pharmaceutically acceptable salts which possess antiallergic, anti-inflammatory and anti-PAF activities, and their production and use.

公开(公告)号：US5155108A

公开(公告)日：1992-10-13

申请号：US648136

申请日：1991-01-30

申请人： Akio Miyake ,  Masaaki Kuwahara ,  Hisashi Kuriki

发明人： Akio Miyake ,  Masaaki Kuwahara ,  Hisashi Kuriki

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The imidazo[1,2-b]pyridazine compounds of the formula: ##STR1## wherein R.sub.1 is a hydrogen or halogen atom, or a lower alkyl group optionally having substituent(s), R.sub.2 an R.sub.3 are, independently, a hydrogen atom, a lower alkyl group optionally having substituent(s), a cycloalkyl group or a phenyl group optionally having substituent(s) or R.sub.2 and R.sub.3 together with the adjacent nitrogen atom to which they bond may form a heterocyclic ring optionally having substituent(s), X is an oxygen atom or S(O)n (n=0 to 2), Alk is a straight or branched chain alkylene group containing 1-10 carbon atoms and optionally having substituent(s), or their pharmaceutically acceptable salts which possess antiallergic, anti-inflammatory and anti-PAF activities, and their production and use.

摘要翻译： 下式的咪唑并[1,2-b]哒嗪化合物：其中R 1是氢或卤素原子，或任选具有取代基的低级烷基，R 2，R 3独立地是 氢原子，任选具有取代基的低级烷基，环烷基或任选具有取代基的苯基，或者R 2和R 3与它们所键合的相邻氮原子一起可以形成任选具有取代基的杂环 X是氧原子或S（O）n（n = 0〜2），Alk是含有1-10个碳原子并且任选具有取代基的直链或支链亚烷基，或其药学上可接受的 具有抗过敏，抗炎和抗PAF活性的盐及其生产和使用。

公开(公告)号：US4893614A

公开(公告)日：1990-01-16

申请号：US188671

申请日：1988-04-29

申请人： Kazuyoshi Takayama ,  Masaaki Kuwahara ,  Shuzo Kimura

发明人： Kazuyoshi Takayama ,  Masaaki Kuwahara ,  Shuzo Kimura

IPC分类号： A61B17/22 ,  A61B17/225 ,  G10K11/00 ,  G10K15/04

CPC分类号： A61B17/2251 ,  G10K11/004 ,  G10K15/043 ,  A61B2017/2253

摘要： An apparatus for disintegrating a calculus in the human body by an underwater shock wave produced outside the human body. The apparatus includes a shock wave generation chamber having an inner surface in the shape of a part of a pseudo-ellipsoid of revolution having an opening therein. Also provided is a shock wave generation source positioned at the first focus of the pseudo-ellipsoid of revolution. In addition, a flexible container housing a liquid is attached to the shock wave generation chamber so that the liquid from the flexible container fills up the shock wave generation chamber. The flexible container containing the liquid is brought into contact with the human body, and the shock wave generation chamber is displaced so as to deform the flexible container, until the calculus in the human body is positioned at the second focus of the pseudo-ellipsoid of revolution. As a result of this positioning of the calculus of the human body at the second focus of the pseudo-ellipsoid of revolution, when a shock wave is generated at the first focus, a sufficiently high pressure can be generated at the second focus so as to disintegrate the calculus.

摘要翻译： 通过在人体外部产生的水下冲击波分解人体中的结石的装置。 该装置包括冲击波产生室，其具有其中具有开口的一部分虚拟椭圆形的内表面。 还提供了一种位于旋转虚拟椭圆体的第一焦点的冲击波发生源。 此外，容纳液体的柔性容器附接到冲击波发生室，使得来自柔性容器的液体填满冲击波发生室。 容纳液体的柔性容器与人体接触，并且冲击波发生室被移动以使柔性容器变形，直到人体内的结石位于假体椭圆体的第二焦点 革命。 由于将人体的微积分定位在旋转伪椭球体的第二焦点处，当在第一焦点产生冲击波时，可以在第二焦点处产生足够高的压力，从而 分解微积分。