公开(公告)号：US10472320B2

公开(公告)日：2019-11-12

申请号：US15736372

申请日：2016-06-23

申请人： Akzo Nobel Chemicals International B.V.

发明人： Adrianus Maria Reichwein ,  Hubertus Johannes Jongen ,  Marjolein Groote

IPC分类号： C07C227/18 ,  C07C227/16

摘要： The present invention relates to a process to prepare N,N′-di(2-hydroxybenzyl) ethylenediamine-N,N′-diacetic acid and salts thereof (HBED) comprising a reaction between formaldehyde, ethylenediamine diacetic acid or a salt thereof (EDDA) and phenol, wherein the reaction mixture contains 0.2 to 1.1 molar equivalents of alkali metal ions on the basis of the molar amount of EDDA and the reaction mixture is processed by a step in which at least part of the organic compounds other than the formed HBED are removed from the reaction mixture, and optionally recycled, during which step at least 50% and up to and including 100% of the alkali metal ions in the reaction mixture are potassium ions, to products obtainable by such process and their use.

公开(公告)号：US10093612B2

公开(公告)日：2018-10-09

申请号：US15736367

申请日：2016-06-23

申请人： Akzo Nobel Chemicals International B.V.

发明人： Adrianus Maria Reichwein ,  Hubertus Johannes Jongen ,  Marjolein Groote

IPC分类号： C07C229/00 ,  C07C227/20

摘要： The present invention relates to a process to prepare N,N′-di(2-hydroxybenzyl) ethylenediamine-N,N′-diacetic acid and salts thereof comprising a reaction between formaldehyde, ethylenediamine diacetic acid or a salt thereof and phenol at a pH of between 3 and 7 and a temperature below 60° C. wherein the reaction mixture contains 0.2 to 1.1 molar equivalents of alkali metalions on the molar amount of EDDA.

公开(公告)号：US20170334833A1

公开(公告)日：2017-11-23

申请号：US15538559

申请日：2015-12-21

申请人： Akzo Nobel Chemicals International B.V.

发明人： Albertus Jacobus Maria Bouwman ,  Hubertus Johannes Jongen ,  Roy Gérard Doppen ,  Martin Heus ,  Elwin Schomaker

IPC分类号： C07C227/26 ,  C07C253/30 ,  C07C231/24 ,  C07C237/06 ,  C07C255/25 ,  C07C253/34

摘要： The present invention relates to alanine N-acetic acid precursors of formula (i) COOM-CH(CH3)-NH—(CH2CN), wherein M is hydrogen (alanine N-monoacetonitrile), or (ii) COOM-CH(CH3)-N—(CH2CN)2, wherein 0 to 50% of all M is sodium or potassium and 50 to 100% of all M is hydrogen (alanine N,N-diacetonitrile and its partial sodium or potassium salts) comprising L-alanine to D-alanine in a range of from 75:25 to 50:50 (L:D), or (iii) COOM-CH(CH3)-N—(CH2CONH2)2, wherein M is hydrogen (alanine N,N-diacetamide), in the form of crystals, and relates to a process to prepare these precursors and their use, especially to give MGMA or MGDA.