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公开(公告)号：US08772293B2
公开(公告)日：2014-07-08
申请号：US13178534
申请日：2011-07-08
申请人： Alan Daniel Brown , Marcel John De Groot , Brian Edward Marron , David James Rawson , Thomas Ryckmans , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West
发明人： Alan Daniel Brown , Marcel John De Groot , Brian Edward Marron , David James Rawson , Thomas Ryckmans , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West
IPC分类号： A01N43/58 , A61K31/50 , A01N43/40 , A61K31/435 , A01N43/56 , A61K31/415 , A01N43/36 , A61K31/40
CPC分类号： C07D237/20 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/501 , A61K31/506 , A61K45/06 , C07D401/12 , C07D403/12 , C07D417/12 , C07D417/14 , A61K2300/00
摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I): or pharmaceutically acceptable salts thereof, wherein Z1, Ra, Rb, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译： 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。 更具体地，本发明涉及式（I）的新型磺酰胺Nav1.7抑制剂或其药学上可接受的盐，其中Z 1，R a，R b，R 1，R 2，R 3，R 4和R 5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
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公开(公告)号：US20120010182A1
公开(公告)日：2012-01-12
申请号：US13178534
申请日：2011-07-08
申请人： Alan Daniel Brown , Marcel John De Groot , Brian Edward Marron , David James Rawson , Thomas Ryckmans , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West
发明人： Alan Daniel Brown , Marcel John De Groot , Brian Edward Marron , David James Rawson , Thomas Ryckmans , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West
IPC分类号： A61K31/501 , C07D403/12 , A61K31/427 , C07D417/14 , A61P25/00 , A61K31/4439 , A61K31/496 , A61K31/506 , C07D401/14 , C07D417/12 , C07D401/12
CPC分类号： C07D237/20 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/501 , A61K31/506 , A61K45/06 , C07D401/12 , C07D403/12 , C07D417/12 , C07D417/14 , A61K2300/00
摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I): or pharmaceutically acceptable salts thereof, wherein Z1, Ra, Rb, R1, R2, R3, R4 and R5 are as defined in the description.Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译： 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。 更具体地，本发明涉及式（I）的新型磺酰胺Nav1.7抑制剂或其药学上可接受的盐，其中Z 1，R a，R b，R 1，R 2，R 3，R 4和R 5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
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公开(公告)号：US20100197655A1
公开(公告)日：2010-08-05
申请号：US12685913
申请日：2010-01-12
申请人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
发明人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
IPC分类号： A61K31/505 , C07D417/12 , A61K31/433 , A61K31/427 , C07D285/08 , C07D263/50 , A61K31/421 , A61K31/4439 , A61K31/506 , C07D261/16 , A61K31/42 , C07D239/69 , A61K31/4245 , C07D401/12 , A61K31/454 , A61K31/44 , C07D213/84 , C07D403/14 , A61K31/501 , C07D405/12 , A61P29/00
CPC分类号： C07D417/12 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D263/50 , C07D275/03 , C07D277/18 , C07D285/08 , C07D401/12 , C07D413/12 , C07D417/14 , C07F9/6539
摘要： The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐，溶剂合物或互变异构体，其制备方法，用于制备的中间体和含有这些化合物的组合物，以及这些化合物的用途，特别是用于 治疗疼痛。
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公开(公告)号：US08541588B2
公开(公告)日：2013-09-24
申请号：US13400356
申请日：2012-02-20
申请人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
发明人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
IPC分类号： C07D277/00 , C07D211/72 , A61K31/44
CPC分类号： C07D417/12 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D263/50 , C07D275/03 , C07D277/18 , C07D285/08 , C07D401/12 , C07D413/12 , C07D417/14 , C07F9/6539
摘要： The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐，溶剂合物或互变异构体，其制备方法，用于制备的中间体和含有这些化合物的组合物，以及这些化合物的用途，特别是用于 治疗疼痛。
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公开(公告)号：US20120149679A1
公开(公告)日：2012-06-14
申请号：US13400356
申请日：2012-02-20
申请人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
发明人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
IPC分类号： A61K31/433 , A61K31/427 , C07D285/08 , C07D263/50 , A61K31/421 , C07D277/52 , A61K31/426 , C07D275/03 , A61K31/425 , A61K31/4439 , A61K31/506 , A61K31/497 , A61K31/501 , C07D401/12 , A61K31/454 , A61P29/00 , C07D417/12
CPC分类号： C07D417/12 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D263/50 , C07D275/03 , C07D277/18 , C07D285/08 , C07D401/12 , C07D413/12 , C07D417/14 , C07F9/6539
摘要： The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐，溶剂合物或互变异构体，其制备方法，用于制备的中间体和含有这些化合物的组合物，以及这些化合物的用途，特别是用于 治疗疼痛。
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公开(公告)号：US08153814B2
公开(公告)日：2012-04-10
申请号：US12685913
申请日：2010-01-12
申请人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
发明人： Serge Beaudoin , Michael Christopher Laufersweiler , Christopher John Markworth , Brian Edward Marron , David Simon Millan , David James Rawson , Steven Michael Reister , Kosuke Sasaki , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West , Shulan Zhou
IPC分类号： C07D277/00 , A61K31/425
CPC分类号： C07D417/12 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D263/50 , C07D275/03 , C07D277/18 , C07D285/08 , C07D401/12 , C07D413/12 , C07D417/14 , C07F9/6539
摘要： The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐，溶剂合物或互变异构体，其制备方法，用于制备的中间体和含有这些化合物的组合物，以及这些化合物的用途，特别是用于 治疗疼痛。
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公开(公告)号：US09145407B2
公开(公告)日：2015-09-29
申请号：US13808625
申请日：2011-06-28
申请人： Christopher John Markworth , Brian Edward Marron , David James Rawson , Robert Ian Storer , Nigel Alan Swain , Christopher William West , Shulan Zhou
发明人： Christopher John Markworth , Brian Edward Marron , David James Rawson , Robert Ian Storer , Nigel Alan Swain , Christopher William West , Shulan Zhou
IPC分类号： A61K31/506 , C07D401/12 , C07D417/12 , C07D417/14 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/501
CPC分类号： C07D417/14 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K31/506 , C07D401/12 , C07D417/12
摘要： The invention relates to new sulfonamide Nav1.7 inhibitors and pharmaceutically acceptable salts thereof, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译： 本发明涉及新的磺酰胺Nav1.7抑制剂及其药学上可接受的盐，其在医学上的用途，含有它们的组合物，其制备方法和用于这些方法的中间体。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
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公开(公告)号：US20130109667A1
公开(公告)日：2013-05-02
申请号：US13808625
申请日：2011-06-28
申请人： Christopher John Markworth , Brian Edward Marron , David James Rawson , Robert Ian Storer , Nigel Alan Swain , Christopher William West , Shulan Zhou
发明人： Christopher John Markworth , Brian Edward Marron , David James Rawson , Robert Ian Storer , Nigel Alan Swain , Christopher William West , Shulan Zhou
IPC分类号： C07D417/14 , C07D401/12 , C07D417/12
CPC分类号： C07D417/14 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K31/506 , C07D401/12 , C07D417/12
摘要： The invention relates to new sulfonamide Nav1.7 inhibitors and pharmaceutically acceptable salts thereof, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译： 本发明涉及新的磺酰胺Nav1.7抑制剂及其药学上可接受的盐，其在医学上的用途，含有它们的组合物，其制备方法和用于此类方法的中间体。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
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公开(公告)号：US09096558B2
公开(公告)日：2015-08-04
申请号：US13808633
申请日：2011-07-01
申请人： Benjamin Scott Greener , Brian Edward Marron , David Simon Millan , David James Rawson , Robert Ian Storer , Nigel Alan Swain
发明人： Benjamin Scott Greener , Brian Edward Marron , David Simon Millan , David James Rawson , Robert Ian Storer , Nigel Alan Swain
IPC分类号： C07D285/08 , C07D417/02 , C07D417/06 , C07D417/12 , A61K31/433 , A61K31/501 , A61K31/4439 , C07D285/135 , C07D401/12 , A61K45/06
CPC分类号： C07D285/135 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K45/06 , C07D285/08 , C07D401/12 , C07D417/12
摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I) or pharmaceutically acceptable salts thereof, wherein X, Y1, Y2, Z, R1, R2 and R3 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译： 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。 更具体地，本发明涉及式（I）的新型磺酰胺Nav1.7抑制剂或其药学上可接受的盐，其中X，Y1，Y2，Z，R1，R2和R3如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
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公开(公告)号：US20130109696A1
公开(公告)日：2013-05-02
申请号：US13808633
申请日：2011-07-01
申请人： Benjamin Scott Greener , Brian Edward Marron , David Simon Millan , David James Rawson , Robert Ian Storer , Nigel Alan Swain
发明人： Benjamin Scott Greener , Brian Edward Marron , David Simon Millan , David James Rawson , Robert Ian Storer , Nigel Alan Swain
IPC分类号： C07D285/135 , C07D285/08 , A61K45/06 , C07D417/12 , A61K31/4439 , C07D401/12 , A61K31/433 , A61K31/501
CPC分类号： C07D285/135 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K45/06 , C07D285/08 , C07D401/12 , C07D417/12
摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I) or pharmaceutically acceptable salts thereof, wherein X, Y1, Y2, Z, R1, R2 and R3 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译： 本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。 更具体地，本发明涉及式（I）的新型磺酰胺Nav1.7抑制剂或其药学上可接受的盐，其中X，Y1，Y2，Z，R1，R2和R3如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。
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