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1.Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore 失效
标题翻译: 用于增强细胞毒素定位到靶位点和细胞毒性组合的预靶向方案因此有用公开(公告)号:US5976535A
公开(公告)日:1999-11-02
申请号:US468513
申请日:1995-06-06
申请人: Alan R. Fritzberg , Paul G. Abrams , John M. Reno , Donald B. Axworthy , Scott S. Graves , Sudhakar Kasina
发明人: Alan R. Fritzberg , Paul G. Abrams , John M. Reno , Donald B. Axworthy , Scott S. Graves , Sudhakar Kasina
IPC分类号: A61K38/00 , A61K47/48 , A61K48/00 , A61K51/04 , A61K51/10 , A61K51/12 , C07F13/00 , C07K14/765 , C07K16/30 , C12N15/87 , A61K45/05
CPC分类号: B82Y5/00 , A61K47/48146 , A61K47/48353 , A61K47/48369 , A61K47/48569 , A61K47/48707 , A61K47/4873 , A61K47/48746 , A61K47/48753 , A61K48/00 , A61K51/0497 , A61K51/1093 , A61K51/1268 , C07F13/005 , C07K14/765 , C07K16/30 , C12N15/87 , A61K2039/505 , A61K2121/00 , A61K2123/00 , A61K38/00 , C07K2317/77
摘要: Methods for targeting cytotoxins to target sites by administration of a combination of conjugates are provided. Novel cytotoxic combinations for use in such methods are also provided.
摘要翻译: 提供了通过给予缀合物的组合将细胞毒素靶向靶位点的方法。 还提供了用于这些方法的新型细胞毒素组合。
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2.Humanized antibodies that bind to the antigen bound by antibody NR-LU-13 失效
标题翻译: 与由抗体NR-LU-13结合的抗原结合的人源化抗体公开(公告)号:US06358710B1
公开(公告)日:2002-03-19
申请号:US08871488
申请日:1997-06-09
申请人: Scott S. Graves , John M. Reno , Robert W. Mallett , Mark D. Hylarides , Stephen M. J. Searle , Andrew H. Henry , Jan T. Pedersen , Anthony R. Rees
发明人: Scott S. Graves , John M. Reno , Robert W. Mallett , Mark D. Hylarides , Stephen M. J. Searle , Andrew H. Henry , Jan T. Pedersen , Anthony R. Rees
IPC分类号: C12P2104
CPC分类号: B82Y5/00 , A61K38/00 , A61K47/68 , A61K47/6898 , A61K2039/505 , C07K1/1133 , C07K16/00 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要: Humanized antibodies which bind the NR-LU-13 antigen, conjugates containing such antibodies, and their use in pretargeting methods and conventional antibody therapy and immunodiagnosis are provided.
摘要翻译: 提供了结合NR-LU-13抗原的人源化抗体,含有这些抗体的缀合物,以及它们在预靶向方法和常规抗体治疗和免疫诊断中的用途。
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3.
公开(公告)号:US20090094715A1
公开(公告)日:2009-04-09
申请号:US12051805
申请日:2008-03-19
申请人: Scott S. Graves , John M. Reno , Robert W. Mallett , Mark D. Hylarides , Stephen M.J. Searle , Andrew H. Henry , Jan T. Pedersen , Anthony R. Rees
发明人: Scott S. Graves , John M. Reno , Robert W. Mallett , Mark D. Hylarides , Stephen M.J. Searle , Andrew H. Henry , Jan T. Pedersen , Anthony R. Rees
IPC分类号: C12N15/82
CPC分类号: B82Y5/00 , A61K38/00 , A61K47/68 , A61K47/6898 , A61K2039/505 , C07K1/1133 , C07K16/00 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要: Humanized antibodies which bind the NR-LU-13 antigen, conjugates containing such antibodies, and their use in pretargeting methods and conventional antibody therapy and immunodiagnosis are provided.
摘要翻译: 提供了结合NR-LU-13抗原的人源化抗体,含有这些抗体的缀合物,以及它们在预靶向方法和常规抗体治疗和免疫诊断中的用途。
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