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    Methods of Treating Aneurysmal Dilatation, Blood Vessel Wall Weakness and Specifically Abdominal Aortic and Thoracic Aneurysm Using Matrix Metalloprotease-2 Inhibitors
    1.
    发明申请
    Methods of Treating Aneurysmal Dilatation, Blood Vessel Wall Weakness and Specifically Abdominal Aortic and Thoracic Aneurysm Using Matrix Metalloprotease-2 Inhibitors 审中-公开
    使用基质金属蛋白酶-2抑制剂治疗动脉瘤扩张，血管壁弱点和具体的腹主动脉和胸腔动脉瘤的方法

    公开(公告)号：US20120270884A1

    公开(公告)日：2012-10-25

    申请号：US13497726

    申请日：2010-09-30

    申请人： Alastair J.J. Wood

    发明人： Alastair J.J. Wood

    IPC分类号： A61K31/495 ,  A61P9/00

    CPC分类号： A61K31/675 ,  A61K31/495 ,  A61K31/55 ,  A61K2300/00

    摘要： The present invention provides methods of treating aneurysmal dilatation, blood vessel wall weakness, and specifically abdominal aortic aneurysm and thoracic aneurysm by inhibiting MMPs and ADAM-IO. Such compounds are useful in the in vitro study of the role of MMPs and ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more MMPs or ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of aneurysmal dilatation or blood vessel wall weakness, for example abdominal aortic aneurysm and thoracic aneurysm. The invention also comprises methods of treating aneurysmal dilatation or blood vessel wall weakness, for example abdominal aortic aneurysm and thoracic aneurysm utilizing the compounds of the invention in conjunction with inhibitors of angiotensin II, including angiotensin II receptor blockers and angiotensin converting enzyme inhibitors, and cyclophillin inhibitors.

    摘要翻译： 本发明提供了通过抑制MMP和ADAM-10来治疗动脉瘤扩张，血管壁虚弱，特别是腹主动脉瘤和胸动脉瘤的方法。 这些化合物可用于体外研究MMPs和ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含根据本发明的一种或多种MMP或ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗动脉瘤扩张或血管壁无力，例如腹主动脉瘤和胸动脉瘤。 本发明还包括利用本发明化合物与血管紧张素II抑制剂（包括血管紧张素II受体阻断剂和血管紧张素转换酶抑制剂）和环磷酰胺转移酶抑制剂联合治疗动脉瘤扩张或血管壁虚弱的方法，例如腹主动脉瘤和胸动脉瘤 抑制剂。

    Methods of Treating Aneurysmal Dilatation, Blood Vessel Wall Weakness and Specifically Abdominal Aortic and Thoracic Aneurysm Using Matrix Metalloprotease-2 Inhibitors
    2.
    发明申请
    Methods of Treating Aneurysmal Dilatation, Blood Vessel Wall Weakness and Specifically Abdominal Aortic and Thoracic Aneurysm Using Matrix Metalloprotease-2 Inhibitors 审中-公开
    使用基质金属蛋白酶-2抑制剂治疗动脉瘤扩张，血管壁弱点和具体的腹主动脉和胸腔动脉瘤的方法

    公开(公告)号：US20110082114A1

    公开(公告)日：2011-04-07

    申请号：US12895073

    申请日：2010-09-30

    申请人： Alastair J.J. Wood

    发明人： Alastair J.J. Wood

    IPC分类号： A61K31/675 ,  A61K31/495 ,  A61K31/55 ,  A61P9/00

    CPC分类号： A61K31/675 ,  A61K31/495 ,  A61K31/55 ,  A61K2300/00

    摘要： The present invention provides methods of treating aneurysmal dilatation, blood vessel wall weakness, and specifically abdominal aortic aneurysm and thoracic aneurysm by inhibiting MMPs and ADAM-10. Such compounds are useful in the in vitro study of the role of MMPs and ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more MMPs or ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of aneurysmal dilatation or blood vessel wall weakness, for example abdominal aortic aneurysm and thoracic aneurysm. The invention also comprises methods of treating aneurysmal dilatation or blood vessel wall weakness, for example abdominal aortic aneurysm and thoracic aneurysm utilizing the compounds of the invention in conjunction with inhibitors of angiotensin II, including angiotensin II receptor blockers and angiotensin converting enzyme inhibitors, and cyclophilin inhibitors.

    摘要翻译： 本发明提供了通过抑制MMP和ADAM-10治疗动脉瘤扩张，血管壁虚弱，特别是腹主动脉瘤和胸动脉瘤的方法。 这些化合物可用于体外研究MMPs和ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含根据本发明的一种或多种MMP或ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗动脉瘤扩张或血管壁无力，例如腹主动脉瘤和胸动脉瘤。 本发明还包括利用本发明化合物与血管紧张素II抑制剂（包括血管紧张素II受体阻断剂和血管紧张素转换酶抑制剂）和亲环蛋白联合治疗动脉瘤扩张或血管壁虚弱的方法，例如腹主动脉瘤和胸动脉瘤 抑制剂。