公开(公告)号：US20240101650A1

公开(公告)日：2024-03-28

申请号：US18256556

申请日：2021-12-15

申请人： Albert Einstein College of Medicine

发明人： Jacqueline M. Achkar ,  Elise Ishida ,  Yanyan Liu ,  Tingting Chen

IPC分类号： C07K16/12 ,  A61P31/06 ,  G01N33/543 ,  G01N33/569

CPC分类号： C07K16/1289 ,  A61P31/06 ,  G01N33/54386 ,  G01N33/5695 ,  C07K2317/21 ,  C07K2317/77 ,  C07K2317/92 ,  G01N2333/35

摘要： Provided are high affinity Mycobacterium tuberculosis arabinomannan-specific antibodies and antigen-binding fragments thereof. Also provided are methods of use and devices employing such Mycobacterium tuberculosis arabinomannan-specific antibodies and antigen-binding fragments thereof.

公开(公告)号：US20230365663A1

公开(公告)日：2023-11-16

申请号：US18309590

申请日：2023-04-28

申请人： Albert Einstein College of Medicine

发明人： Jacqueline M. Achkar ,  Jonathan Lai ,  Elise Ishida ,  Daniel Hofmann ,  Tingting Chen

IPC分类号： C07K16/12 ,  G01N33/569 ,  G01N33/53 ,  G01N33/543

CPC分类号： C07K16/1289 ,  G01N33/5302 ,  G01N33/54388 ,  G01N33/5695 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565

摘要： Provided are high affinity Mycobacterium tuberculosis capsule-specific antibodies and fragments thereof, as well as methods of use and devices employing such antibodies and/or fragments.

公开(公告)号：US20220326236A1

公开(公告)日：2022-10-13

申请号：US17764693

申请日：2020-10-02

申请人： Albert Einstein College of Medicine

发明人： Jacqueline M. Achkar ,  Eustache Paramithiotis

IPC分类号： G01N33/569 ,  G01N33/68

摘要： This disclosure describes markers that are associated with active tuberculosis (TB) and demonstrates that the disclosed markers can be used as a biomarker for determining whether a subject has or is at risk of having active TB and for the early detection of HIV-associated TB. This disclosure also provides methods of screening subjects who are thought to be at risk for developing active TB, methods of determining the efficacy of therapeutic regimens for preventing or treating active TB, and methods of identifying anti-TB agents.

公开(公告)号：US11643455B2

公开(公告)日：2023-05-09

申请号：US17247532

申请日：2020-12-15

申请人： Albert Einstein College of Medicine

发明人： Jacqueline M. Achkar ,  Jonathan Lai ,  Elise Ishida ,  Daniel Hofmann ,  Tingting Chen

IPC分类号： C07K16/12 ,  A61K39/00 ,  G01N33/569 ,  G01N33/53

CPC分类号： C07K16/1289 ,  G01N33/5302 ,  G01N33/5695 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565

摘要： Provided are high affinity Mycobacterium tuberculosis capsule-specific antibodies and fragments thereof, as well as methods of use and devices employing such antibodies and/or fragments.

公开(公告)号：US20210163578A1

公开(公告)日：2021-06-03

申请号：US17047256

申请日：2019-04-12

申请人： Albert Einstein College of Medicine

发明人： Jacqueline M. Achkar ,  Jonathan Lai ,  Elise Ishida ,  Daniel Hofmann ,  Tingting Chen

IPC分类号： C07K16/12 ,  A61P31/06 ,  G01N33/569

摘要： Provided are high affinity Mycobacterium tuberculosis capsule-specific antibodies and fragments thereof, as well as methods of use and devices employing such antibodies and/or fragments.

公开(公告)号：US20210130443A1

公开(公告)日：2021-05-06

申请号：US17247532

申请日：2020-12-15

申请人： Albert Einstein College of Medicine

发明人： Jacqueline M. Achkar ,  Jonathan Lai ,  Elise Ishida ,  Daniel Hofmann ,  Tingting Chen

IPC分类号： C07K16/12 ,  G01N33/569

摘要： Provided are high affinity Mycobacterium tuberculosis capsule-specific antibodies and fragments thereof, as well as methods of use and devices employing such antibodies and/or fragments.