专利检索 ap:("Albert Einstein College of Medicine" OR "Montefiore Medical Center") AND inv:"Yiyu Zou" 第 1 页

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发明申请
RICTOR-TARGETED THERAPY IN THE MANAGEMENT OF BRAIN METASTASES 有权

公开(公告)号：US20210205322A1

公开(公告)日：2021-07-08

申请号：US17144715

申请日：2021-01-08

申请人： Albert Einstein College of Medicine , Montefiore Medical Center

发明人： Haiying Cheng , Roman Perez-Soler , Balazs Halmos , Ni Fan , Yiyu Zou

IPC分类号： A61K31/5377 , A61P35/00 , A61P35/04 , A61K31/519 , A61K31/426 , A61K31/517 , A61K31/506 , A61K31/53 , A61K31/4545 , A61K31/47 , A61K31/4745 , A61K31/4985 , A61K31/496 , A61K31/437

摘要： A method of treating metastases (e.g., brain metastases) in a patient with cancer (e.g., lung cancer) and at risk for metastases, exhibiting symptoms of metastases, or identified with metastases includes administering a therapeutically effective amount of a RICTOR inhibitor for the treatment of metastases. A method of reducing resistance to an EGFR, MET or AKT inhibitor in a cancer patient being administered the EGFR. MET or AKT inhibitor comprises co-administering a therapeutically effective amount of a RICTOR inhibitor and the EGFR, MET or AKT inhibitor. RICTOR inhibitors include compounds of formulas I-IV.