公开(公告)号：US20150057336A1

公开(公告)日：2015-02-26

申请号：US14484972

申请日：2014-09-12

申请人： Alcon Research, Ltd.

发明人： Jon E. Chatterton ,  Abbot F. Clark ,  David P. Bingaman ,  Martin B. Wax ,  Adrian M. Timmers

IPC分类号： C12N15/113

CPC分类号： C12N15/1138 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/53 ,  C12N2310/531

摘要： RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions associated with elevated intraocular pressure (TOP), including glaucoma and ocular hypertension.

摘要翻译： 通过沉默TNFα细胞表面受体TNF受体-1（TNFR1）mRNA表达或沉默TNFα转化酶（TACE / ADAM17）mRNA表达，提供RNA干扰抑制肿瘤坏死因子α（TNFα）。 特别是使TNFα靶标沉默可用于治疗患有TNFα相关病症或出现TNFα相关病症风险的患者，如与眼内压升高（TOP）相关的眼部疾病，包括青光眼和高眼压症。

公开(公告)号：US20140357696A1

公开(公告)日：2014-12-04

申请号：US14270197

申请日：2014-05-05

申请人： ALCON RESEARCH, LTD.

发明人： Jon E. Chatterton ,  Abbot F. Clark ,  David P. Bingaman ,  Martin B. Wax ,  Adrian M. Timmers

IPC分类号： C12N15/113

CPC分类号： C12N15/1138 ,  C12N15/113 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/31 ,  C12N2310/319 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/53 ,  C12N2310/531

摘要： RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition, such as ocular angiogenesis, retinal ischemia, and diabetic retinopathy.

摘要翻译： 通过沉默TNFα细胞表面受体TNF受体-1（TNFR1）mRNA表达或沉默TNFα转化酶（TACE / ADAM17）mRNA表达，提供RNA干扰抑制肿瘤坏死因子α（TNFα）。 特别是使TNFα靶标沉默可用于治疗患有TNFα相关病症或出现TNFα相关病症如眼血管生成，视网膜缺血和糖尿病性视网膜病变的风险的患者。

公开(公告)号：US20130177580A1

公开(公告)日：2013-07-11

申请号：US13765216

申请日：2013-02-12

申请人： Alcon Research, Ltd.

发明人： Jon E. Chatterton ,  Abbot F. Clark

IPC分类号： A61K31/7088

CPC分类号： C12N15/113 ,  A61K9/0048 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/64 ,  A61K47/644 ,  A61K47/6849 ,  C12N15/87 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/3513 ,  C12N2320/32

摘要： The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a transferrin receptor (TfR). Therapeutic uses for the conjugates are also provided.