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公开(公告)号：US20070238754A1
公开(公告)日：2007-10-11
申请号：US11801727
申请日：2007-05-10
申请人： Alexander Mayweg , Hans Marty , Werner Mueller , Robert Narquizian , Werner Neidhart , Philippe Pflieger , Stephan Roever
发明人： Alexander Mayweg , Hans Marty , Werner Mueller , Robert Narquizian , Werner Neidhart , Philippe Pflieger , Stephan Roever
IPC分类号： A61K31/4164 , A61K31/40 , A61K31/454 , C07D207/335 , C07D233/64 , C07D401/12
CPC分类号： C07D231/12 , C07D207/34 , C07D233/56 , C07D233/90 , C07D249/08 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, m and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.
摘要翻译： 本发明涉及式（I）的化合物，其中R 1，R 2，R 3，R 4， >，R 5，R 6，m和X如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与调节CB1受体相关的疾病。
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公开(公告)号：US07579369B2
公开(公告)日：2009-08-25
申请号：US11801727
申请日：2007-05-10
申请人： Alexander Mayweg , Hans Peter Marty , Werner Mueller , Robert Narquizian , Werner Neidhart , Philippe Pflieger , Stephan Roever
发明人： Alexander Mayweg , Hans Peter Marty , Werner Mueller , Robert Narquizian , Werner Neidhart , Philippe Pflieger , Stephan Roever
IPC分类号： A61K31/40 , C07D233/64
CPC分类号： C07D231/12 , C07D207/34 , C07D233/56 , C07D233/90 , C07D249/08 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, m and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.
摘要翻译： 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，m和X如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 该化合物可用于治疗和/或预防与调节CB1受体相关的疾病。
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公开(公告)号：US07294644B2
公开(公告)日：2007-11-13
申请号：US10743642
申请日：2003-12-22
申请人： Alexander Mayweg , Hans Peter Marty , Werner Mueller , Robert Narquizian , Werner Neidhart , Philippe Pflieger , Stephan Roever
发明人： Alexander Mayweg , Hans Peter Marty , Werner Mueller , Robert Narquizian , Werner Neidhart , Philippe Pflieger , Stephan Roever
IPC分类号： A61K31/40 , A61K31/4164
CPC分类号： C07D231/12 , C07D207/34 , C07D233/56 , C07D233/90 , C07D249/08 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, m and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.
摘要翻译： 本发明涉及式（I）的化合物，其中R 1，R 2，R 3，R 4， >，R 5，R 6，m和X如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与调节CB1受体相关的疾病。
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公开(公告)号：US20050250769A1
公开(公告)日：2005-11-10
申请号：US11125382
申请日：2005-05-09
IPC分类号： A61K31/395 , C07D207/34 , C07D405/06 , A61K31/541 , A61K31/4025 , A61K31/4178 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D405/06 , C07D207/34
摘要： The present invention relates to compounds of formula I and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐。 该化合物可用于治疗和/或预防与调节CB1受体相关的疾病。
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公开(公告)号：US07563910B2
公开(公告)日：2009-07-21
申请号：US11125382
申请日：2005-05-09
IPC分类号： A61K31/4025 , C07D403/06 , C07D405/06
CPC分类号： C07D405/06 , C07D207/34
摘要： The present invention relates to compounds of formula I and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐。 该化合物可用于治疗和/或预防与调节CB1受体相关的疾病。
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公开(公告)号：US20060089367A1
公开(公告)日：2006-04-27
申请号：US11257885
申请日：2005-10-25
IPC分类号： A61K31/496 , C07D403/02 , A61K31/454 , A61K31/405
CPC分类号： C07D235/12 , C07D209/12 , C07D401/06
摘要： Provided are compounds of the formula I: and pharmaceutically acceptable salts thereof, processes for making said compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said compound and pharmaceutically acceptable salts thereof, and methods of using said compounds. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.
摘要翻译： 提供式I化合物及其药学上可接受的盐，制备所述化合物及其药学上可接受的盐的方法，包含所述化合物的药物组合物及其药学上可接受的盐以及使用所述化合物的方法。 该化合物可用于治疗和/或预防与调节CB1受体相关的疾病。
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公开(公告)号：US07384945B2
公开(公告)日：2008-06-10
申请号：US11257885
申请日：2005-10-25
IPC分类号： A61K31/497 , A61K31/40 , A01N43/38 , C07D401/00 , C07D211/78 , C07D211/90 , C07D213/81 , C07D209/42 , C07D403/00
CPC分类号： C07D235/12 , C07D209/12 , C07D401/06
摘要： Provided are compounds of the formula I: and pharmaceutically acceptable salts thereof, processes for making said compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said compound and pharmaceutically acceptable salts thereof, and methods of using said compounds. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.
摘要翻译： 提供式I化合物及其药学上可接受的盐，制备所述化合物及其药学上可接受的盐的方法，包含所述化合物的药物组合物及其药学上可接受的盐以及使用所述化合物的方法。 该化合物可用于治疗和/或预防与调节CB1受体相关的疾病。
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公开(公告)号：US20080234290A1
公开(公告)日：2008-09-25
申请号：US12114219
申请日：2008-05-02
IPC分类号： A61K31/496 , C07D403/06 , C07D235/04 , A61K31/4184 , C07D209/42 , A61K31/405
CPC分类号： C07D235/12 , C07D209/12 , C07D401/06
摘要： Provided are compounds of the formula I: and pharmaceutically acceptable salts thereof, processes for making said compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said compound and pharmaceutically acceptable salts thereof, and methods of using said compounds. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.
摘要翻译： 提供式I化合物及其药学上可接受的盐，制备所述化合物及其药学上可接受的盐的方法，包含所述化合物的药物组合物及其药学上可接受的盐以及使用所述化合物的方法。 该化合物可用于治疗和/或预防与调节CB1受体相关的疾病。
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公开(公告)号：US07572801B2
公开(公告)日：2009-08-11
申请号：US11801863
申请日：2007-05-11
申请人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters , Fabienne Ricklin , Stephan Roever
发明人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters , Fabienne Ricklin , Stephan Roever
IPC分类号： A61K31/519 , C07D471/04 , A61P9/10 , A61P3/00 , A61P3/10
CPC分类号： C07D471/04
摘要： The invention is concerned with novel pyridopyrimidinone derivatives of formula (I): wherein R1 to R8, X, Y, m and n are as defined in the description and in the claims. The compounds of the present invention are HM74A agonists with improved properties compared to niacin and can be used for the treatment and/or prevention of diseases such as dyslipidemia, atherosclerosis, diabetes, metabolic syndrome, and other related diseases associated with HM74A.
摘要翻译： 本发明涉及式（I）的新颖的吡啶并嘧啶酮衍生物：其中R1至R8，X，Y，m和n如说明书和权利要求中所定义。 本发明的化合物是与烟酸相比具有改进性质的HM74A激动剂，可用于治疗和/或预防诸如血脂异常，动脉粥样硬化，糖尿病，代谢综合征和与HM74A相关的其它相关疾病的疾病。
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公开(公告)号：US20070275987A1
公开(公告)日：2007-11-29
申请号：US11801863
申请日：2007-05-11
申请人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters , Fabienne Ricklin , Stephan Roever
发明人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters , Fabienne Ricklin , Stephan Roever
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04
摘要： The invention is concerned with novel pyridopyrimidinone derivatives of formula (I): wherein R1 to R8, X, Y, m and n are as defined in the description and in the claims. The compounds of the present invention are HM74A agonists with improved properties compared to niacin and can be used for the treatment and/or prevention of diseases such as dyslipidemia, atherosclerosis, diabetes, metabolic syndrome, and other related diseases associated with HM74A.
摘要翻译： 本发明涉及式（I）的新型吡啶并嘧啶酮衍生物：其中R 1至R 8，X，Y，m和n如说明书和 索赔。 本发明的化合物是与烟酸相比具有改进性质的HM74A激动剂，可用于治疗和/或预防诸如血脂异常，动脉粥样硬化，糖尿病，代谢综合征和与HM74A相关的其它相关疾病的疾病。
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