公开(公告)号：US08956157B2

公开(公告)日：2015-02-17

申请号：US13361969

申请日：2012-01-31

申请人： Alexander Philippovich Rutberg ,  Philipp Grigorevich Rutberg ,  Viktor Andreevich Kolikov ,  Galina Boricovna Shtorina ,  Harry D. Fair

发明人： Alexander Philippovich Rutberg ,  Philipp Grigorevich Rutberg ,  Viktor Andreevich Kolikov ,  Galina Boricovna Shtorina ,  Harry D. Fair

IPC分类号： A61C19/06

CPC分类号： A61C17/02 ,  A61C19/063

摘要： An apparatus for the generation of metallic and metal oxide nanoparticles for use in the treatment of periodontal disease has a discharge chamber with a controlled flow of water, the water flowing through a plasma gap formed by electrodes, the electrodes having a pulsed voltage applied to create a plasma discharge, the pulse duration chosen to maximize the generation of nanoparticles from the electrodes which are in the range of 10 nm to 50 nm. The discharge chamber flow rate and pulse duration is controlled to maintain a particular temperature differential across the plasma gap to additionally optimize the nanoparticles population for the desired 10 nm to 20 nm size range having negative surface electric charge. The nanoparticles thereby formed may thereafter be applied to a subject in need thereof as an irrigation treatment, or as a paste applied directly to a region of periodontal disease.

摘要翻译： 用于产生用于治疗牙周病的金属和金属氧化物纳米颗粒的装置具有具有受控流动的水的排放室，水流过由电极形成的等离子体间隙，电极具有施加的脉冲电压以产生 等离子体放电，选择脉冲持续时间以最大化从10nm至50nm范围内的电极产生纳米颗粒。 控制放电室流速和脉冲持续时间以保持跨等离子体间隙的特定温差，以在具有负表面电荷的期望的10nm至20nm尺寸范围内另外优化纳米颗粒群。 由此形成的纳米颗粒此后可以作为灌洗处理施用于有需要的受试者，或者直接施用于牙周病的区域。

公开(公告)号：US20130196286A1

公开(公告)日：2013-08-01

申请号：US13361969

申请日：2012-01-31

申请人： Alexander Philippovich Rutberg ,  Philipp Grigorevich Rutberg ,  Viktor Andreevich KOLIKOV ,  Galina Boricovna SHTORINA ,  Harry D. FAIR

发明人： Alexander Philippovich Rutberg ,  Philipp Grigorevich Rutberg ,  Viktor Andreevich KOLIKOV ,  Galina Boricovna SHTORINA ,  Harry D. FAIR

IPC分类号： A61C19/06 ,  A61C17/02

CPC分类号： A61C17/02 ,  A61C19/063

摘要： An apparatus for the generation of metallic and metal oxide nanoparticles for use in the treatment of periodontal disease has a discharge chamber with a controlled flow of water, the water flowing through a plasma gap formed by electrodes, the electrodes having a pulsed voltage applied to create a plasma discharge, the pulse duration chosen to maximize the generation of nanoparticles from the electrodes which are in the range of 10 nm to 50 nm. The discharge chamber flow rate and pulse duration is controlled to maintain a particular temperature differential across the plasma gap to additionally optimize the nanoparticles population for the desired 10 nm to 20 nm size range having negative surface electric charge. The nanoparticles thereby formed may thereafter be applied to a subject in need thereof as an irrigation treatment, or as a paste applied directly to a region of periodontal disease.

摘要翻译： 用于产生用于治疗牙周病的金属和金属氧化物纳米颗粒的装置具有具有受控流动的水的排放室，水流过由电极形成的等离子体间隙，电极具有施加的脉冲电压以产生 等离子体放电，选择脉冲持续时间以最大化从10nm至50nm范围内的电极产生纳米颗粒。 控制放电室流速和脉冲持续时间以保持跨等离子体间隙的特定温差，以在具有负表面电荷的期望的10nm至20nm尺寸范围内另外优化纳米颗粒群。 由此形成的纳米颗粒此后可以作为灌洗处理施用于有需要的受试者，或者直接施用于牙周病的区域。