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公开(公告)号:US20100004213A1
公开(公告)日:2010-01-07
申请号:US12324783
申请日:2008-11-26
申请人: Alexander R. Abbas , Hilary Clark , Lauri Diehl , Charles Lees , Colin L. Noble , Jack Satsangi
发明人: Alexander R. Abbas , Hilary Clark , Lauri Diehl , Charles Lees , Colin L. Noble , Jack Satsangi
IPC分类号: A61K31/606 , C12Q1/68 , A61K31/56 , A61P1/00
CPC分类号: G01N33/564 , A61K31/56 , A61K31/606 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要: The present invention relates to methods of gene expression profiling for inflammatory bowel disease pathogenesis, in which the differential expression in a test sample from a mammalian subject of one or more IBD markers relative to a control is determined, wherein the differential expression in the lest sample is indicative of an IBD in the mammalian subject from which the lest sample was obtained.
摘要翻译: 本发明涉及炎症性肠病发病机理的基因表达谱的方法,其中测定来自哺乳动物受试者的一种或多种IBD标记相对于对照的测试样品中的差异表达,其中最小样品中的差异表达 指示获得最少样品的哺乳动物受试者中的IBD。
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公开(公告)号:US20110033486A1
公开(公告)日:2011-02-10
申请号:US12839340
申请日:2010-07-19
申请人: Alexander R. ABBAS , Hilary Clark , Lauri Diehl , Charles Lees , Colin L. Noble , Jack Satsangi
发明人: Alexander R. ABBAS , Hilary Clark , Lauri Diehl , Charles Lees , Colin L. Noble , Jack Satsangi
IPC分类号: A61K39/00 , C12Q1/68 , A61P29/00 , A61K31/56 , A61K31/609
CPC分类号: C12Q1/6883 , C12Q2600/158
摘要: The present invention relates to methods of gene expression profiling for inflammatory bowel disease pathogenesis, in which the differential expression in a test sample from a mammalian subject of one or more IBD markers relative to a control is determined, wherein the differential expression in the test sample is indicative of an IBD in the mammalian subject from which the test sample was obtained.
摘要翻译: 本发明涉及炎症性肠病发病机理的基因表达谱的方法,其中测定来自一个或多个IBD标记物的哺乳动物受试者相对于对照的测试样品中的差异表达,其中测试样品中的差异表达 指示获得测试样品的哺乳动物受试者中的IBD。
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公开(公告)号:US20090155788A1
公开(公告)日:2009-06-18
申请号:US12125724
申请日:2008-05-22
申请人: Alexander R. Abbas , Lauri Diehl , Charles Lees , Colin L. Noble , Jack Satsangi
发明人: Alexander R. Abbas , Lauri Diehl , Charles Lees , Colin L. Noble , Jack Satsangi
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6883 , C12Q2600/106 , C12Q2600/154 , C12Q2600/158
摘要: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting decreased expression of Indian Hedgehog (Ihh) and/or increased expression of Defensin A5 (DefA5) and/or Defensin A6 (DefA6) in the tissues or cells of the mammal relative to a control.
摘要翻译: 本发明提供了一种通过检测印度刺猬(Ihh)的表达降低和/或防御素A5(DefA5)和/或防御素A6(DefA5)和/或防御素A6的表达增加而检测哺乳动物胃肠组织或细胞中炎性肠病的存在的方法 DefA6)相对于对照组在哺乳动物的组织或细胞中。
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公开(公告)号:US20090186034A1
公开(公告)日:2009-07-23
申请号:US12004525
申请日:2007-12-19
申请人: Alexander Abbas , Hilary Clark , Lauri Diehl
发明人: Alexander Abbas , Hilary Clark , Lauri Diehl
IPC分类号: C12Q1/68 , A61K31/4402 , A61K31/195 , A61K31/196 , A61K31/58 , A61K31/573 , A61K31/52 , A61K31/519 , A61K38/13 , A61K39/395
CPC分类号: C12Q1/6883 , A61K31/195 , A61K31/196 , A61K31/4402 , A61K31/519 , A61K31/52 , A61K31/573 , A61K31/58 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要: The present invention relates to methods of gene expression profiling for inflammatory bowel disease pathogenesis, in which the differential expression in a test sample from a mammalian subject of one or more IBD markers relative to a control is determined, wherein the differential expression in the test sample is indicative of an IBD in the mammalian subject from which the test sample was obtained.
摘要翻译: 本发明涉及炎症性肠病发病机理的基因表达谱的方法,其中测定来自一个或多个IBD标记物的哺乳动物受试者相对于对照的测试样品中的差异表达,其中测试样品中的差异表达 指示获得测试样品的哺乳动物受试者中的IBD。
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5.
公开(公告)号:US09562097B2
公开(公告)日:2017-02-07
申请号:US14129053
申请日:2012-06-29
申请人: Lauri Diehl , Jennifer Bates , Tao Sai
发明人: Lauri Diehl , Jennifer Bates , Tao Sai
IPC分类号: A61K39/395 , C07K16/28 , A61K39/00
CPC分类号: C07K16/2803 , A61K2039/505 , C07K2317/75 , C07K2319/30
摘要: This invention relates to compositions comprising anti-CD83 agonist antibodies and methods of treating autoimmune disorders (such as inflammatory bowel disease) with anti-CD83 agonist antibodies, as well as articles of manufacture comprising anti-CD83 agonist antibodies.
摘要翻译: 本发明涉及包含抗CD83激动剂抗体的组合物和用抗CD83激动剂抗体治疗自身免疫疾病(如炎性肠病)的方法,以及包含抗CD83激动剂抗体的制品。
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6.
公开(公告)号:US20140286950A1
公开(公告)日:2014-09-25
申请号:US14129053
申请日:2012-06-29
申请人: Lauri Diehl , Jennifer Bates , Tao Sai
发明人: Lauri Diehl , Jennifer Bates , Tao Sai
IPC分类号: C07K16/28
CPC分类号: C07K16/2803 , A61K2039/505 , C07K2317/75 , C07K2319/30
摘要: This invention relates to compositions comprising anti-CD83 agonist antibodies and methods of treating autoimmune disorders (such as inflammatory bowel disease) with anti-CD83 agonist antibodies, as well as articles of manufacture comprising anti-CD83 agonist antibodies.
摘要翻译: 本发明涉及包含抗CD83激动剂抗体的组合物和用抗CD83激动剂抗体治疗自身免疫疾病(如炎性肠病)的方法,以及包含抗CD83激动剂抗体的制品。
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公开(公告)号:US20130261025A1
公开(公告)日:2013-10-03
申请号:US13565685
申请日:2012-08-02
申请人: Lauri Diehl , Kenneth Flanagan , Lian Mo
发明人: Lauri Diehl , Kenneth Flanagan , Lian Mo
CPC分类号: C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6893
摘要: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.
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公开(公告)号:US08257923B2
公开(公告)日:2012-09-04
申请号:US12984562
申请日:2011-01-04
申请人: Lauri Diehl , Kenneth Flanagan , Lian Mo
发明人: Lauri Diehl , Kenneth Flanagan , Lian Mo
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6893
摘要: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.
摘要翻译: 本发明提供了一种通过检测哺乳动物组织或细胞中LY6基因相对于对照而增加的表达来检测胃肠组织或哺乳动物细胞中炎症性肠病的存在的方法。
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公开(公告)号:US20110177504A1
公开(公告)日:2011-07-21
申请号:US12984562
申请日:2011-01-04
申请人: Lauri Diehl , Kenneth Flanagan , Lian Mo
发明人: Lauri Diehl , Kenneth Flanagan , Lian Mo
CPC分类号: C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6893
摘要: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.
摘要翻译: 本发明提供了一种通过检测哺乳动物组织或细胞中LY6基因相对于对照而增加的表达来检测胃肠组织或哺乳动物细胞中炎症性肠病的存在的方法。
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公开(公告)号:US07875431B2
公开(公告)日:2011-01-25
申请号:US12036183
申请日:2008-02-22
申请人: Lauri Diehl , Kenneth Flanagan , Lian Mo
发明人: Lauri Diehl , Kenneth Flanagan , Lian Mo
CPC分类号: C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6893
摘要: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.
摘要翻译: 本发明提供了一种通过检测哺乳动物组织或细胞中LY6基因相对于对照而增加的表达来检测胃肠组织或哺乳动物细胞中炎症性肠病的存在的方法。
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