公开(公告)号：US07906483B2

公开(公告)日：2011-03-15

申请号：US12380063

申请日：2009-02-23

申请人： Alexandra Lucas ,  Z. Robert Zhong ,  D. Grant McFadden

发明人： Alexandra Lucas ,  Z. Robert Zhong ,  D. Grant McFadden

IPC分类号： A61K38/17

CPC分类号： A61K38/55 ,  A61K2300/00

摘要： Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an anti-rejection agent, such as cyclosporin, and a pharmaceutically acceptable carrier to a subject in need of such treatment. The compositions and methods are useful for treating acute and chronic allograft and xenograft transplant rejection in mammals.

摘要翻译： 提供了哺乳动物移植受体中用于治疗移植排斥的组合物和方法。 该方法包括向需要这种治疗的受试者施用治疗有效量的Serp-1，其类似物和其生物活性片段与抗排斥剂如环孢菌素和药学上可接受的载体。 组合物和方法可用于治疗哺乳动物中的急性和慢性同种异体移植物和异种移植物排斥反应。

公开(公告)号：US20090221472A1

公开(公告)日：2009-09-03

申请号：US12380063

申请日：2009-02-23

申请人： Alexandra Lucas ,  Z. Robert Zhong ,  D. Grant McFadden

发明人： Alexandra Lucas ,  Z. Robert Zhong ,  D. Grant McFadden

IPC分类号： A61K38/12 ,  A61K38/16 ,  A61P39/06

CPC分类号： A61K38/55 ,  A61K2300/00

摘要： Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an anti-rejection agent, such as cyclosporin, and a pharmaceutically acceptable carrier to a subject in need of such treatment. The compositions and methods are useful for treating acute and chronic allograft and xenograft transplant rejection in mammals.

摘要翻译： 提供了哺乳动物移植受体中用于治疗移植排斥的组合物和方法。 该方法包括向需要这种治疗的受试者施用治疗有效量的Serp-1，其类似物和其生物活性片段与抗排斥剂如环孢菌素和药学上可接受的载体。 组合物和方法可用于治疗哺乳动物中的急性和慢性同种异体移植物和异种移植物排斥反应。