公开(公告)号：US20050059738A1

公开(公告)日：2005-03-17

申请号：US10948026

申请日：2004-09-23

申请人： Alfred Ajami ,  Carrie Sims ,  Mitchell Fink

发明人： Alfred Ajami ,  Carrie Sims ,  Mitchell Fink

IPC分类号： A61K31/22 ,  A61K31/235 ,  A61K33/00 ,  A61K33/06

CPC分类号： A61K31/235 ,  A61K31/22 ,  A61K33/00 ,  A61K2300/00

摘要： A therapeutic composition comprising an alkyl, aralkyl, alkoxyalkyl or carboxyalkyl ester of 2ketoalkanoic acid and a component for inducing and stabilizing the enol resonance form of the ester at physiological pH values is disclosed. The composition of the invention further comprises a pharmaceutically acceptable carier vehicle in which the enol resonance form of the ester is stabilized at physiological pH values. Formulations containing the compositions of the invention permit the successful use of 2-ketoalkanoic acid esters, e.g., pyruvic acid esters, to treat, e.g., is chemic events, shock, organ reanimation, resuscitation and other recognized pyruvate-effective treatments. The compositions of the inventions are also useful in a process for preserving organ parts, organs or limbs removed from a living mammal and in need of preservation, e.g., for later transplantation to an organ recipient.

摘要翻译： 公开了一种治疗组合物，其包含2-酮链烷酸的烷基，芳烷基，烷氧基烷基或羧烷基酯，以及用于在生理pH值下诱导和稳定酯的烯醇共振形式的组分。 本发明的组合物还包含药学上可接受的载体，其中酯的烯醇共振形式在生理pH值下稳定。 含有本发明组合物的制剂允许成功地使用2-酮链烷酸酯，例如丙酮酸酯，以治疗例如化学事件，休克，器官恢复，复苏和其他公认的丙酮酸有效治疗。 本发明的组合物还可用于保存从活的哺乳动物中除去并需要保存的器官部分，器官或四肢的方法，例如用于随后移植至器官接收者。