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公开(公告)号：US20120121667A1
公开(公告)日：2012-05-17
申请号：US13357723
申请日：2012-01-25
申请人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
发明人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
IPC分类号： A61K9/00 , A61K31/485 , A61P25/04
CPC分类号： A61K31/485 , A61K9/0002 , A61K9/4808 , A61K9/5026 , A61K9/5078
摘要： Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 层将拮抗剂与激动剂彼此物理分离。 还提供了制备这种药物组合物的方法。 还证明了使用这种组合物治疗疼痛的方法。
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公开(公告)号：US20100151014A1
公开(公告)日：2010-06-17
申请号：US12336418
申请日：2008-12-16
申请人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
发明人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
CPC分类号： A61K31/485 , A61K9/0002 , A61K9/4808 , A61K9/5026 , A61K9/5078
摘要： Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.
摘要翻译： 本文提供的药物组合物包含拮抗剂，激动剂，密封涂层和螯合聚合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 层将拮抗剂与激动剂彼此物理分离。 还提供了制备这种药物组合物的方法。 还证明了使用这种组合物治疗疼痛的方法。
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公开(公告)号：US08623418B2
公开(公告)日：2014-01-07
申请号：US12336267
申请日：2008-12-16
申请人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
发明人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
CPC分类号： A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/185 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 还提供了制备这种药物组合物的方法。 还证明了使用这种组合物治疗疼痛的方法。
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公开(公告)号：US20100152221A1
公开(公告)日：2010-06-17
申请号：US12336267
申请日：2008-12-16
申请人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
发明人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
IPC分类号： A61K31/485
CPC分类号： A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/185 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 还提供了制备这种药物组合物的方法。 还证明了使用这种组合物治疗疼痛的方法。
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公开(公告)号：US20100143483A1
公开(公告)日：2010-06-10
申请号：US12710016
申请日：2010-02-22
申请人： Frank MATTHEWS , Garth Boehm , Lijuan Tang , Alfred Liang
发明人： Frank MATTHEWS , Garth Boehm , Lijuan Tang , Alfred Liang
IPC分类号： A61K9/14 , A61K31/485 , A61P25/04
CPC分类号： A61K9/5078 , A61K9/16 , A61K9/167 , A61K9/1676 , A61K9/4808 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5073 , A61K31/485
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 还提供了制备这种药物组合物的方法。
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6.发明授权公开(公告)号：US08846104B2
公开(公告)日：2014-09-30
申请号：US13371760
申请日：2012-02-13
申请人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
发明人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
CPC分类号： A61K9/5078 , A61K9/16 , A61K9/167 , A61K9/1676 , A61K9/4808 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5073 , A61K31/485
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 还提供了制备这种药物组合物的方法。
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7.发明授权Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist 有权包含阿片样物质拮抗剂和阿片样物质激动剂的滥用威慑性多层药物组合物公开(公告)号：US08158156B2
公开(公告)日：2012-04-17
申请号：US11820499
申请日：2007-06-19
申请人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
发明人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
CPC分类号： A61K9/5078 , A61K9/16 , A61K9/167 , A61K9/1676 , A61K9/4808 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5073 , A61K31/485
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 还提供了制备这种药物组合物的方法。
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公开(公告)号：US07682634B2
公开(公告)日：2010-03-23
申请号：US12399923
申请日：2009-03-06
申请人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
发明人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
CPC分类号： A61K9/5078 , A61K9/16 , A61K9/167 , A61K9/1676 , A61K9/4808 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5073 , A61K31/485
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 还提供了制备这种药物组合物的方法。
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公开(公告)号：US20120189705A1
公开(公告)日：2012-07-26
申请号：US13427986
申请日：2012-03-23
申请人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
发明人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
IPC分类号： A61K9/14 , A61P25/04 , A61K31/4748
CPC分类号： A61K9/5078 , A61K9/16 , A61K9/167 , A61K9/1676 , A61K9/4808 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5073 , A61K31/485
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are . also provided.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 制造这种药物组合物的方法是。 也提供。
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公开(公告)号：US07682633B2
公开(公告)日：2010-03-23
申请号：US12399918
申请日：2009-03-06
申请人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
发明人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
CPC分类号： A61K9/5078 , A61K9/16 , A61K9/167 , A61K9/1676 , A61K9/4808 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5073 , A61K31/485
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 还提供了制备这种药物组合物的方法。
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