公开(公告)号：US08007776B2

公开(公告)日：2011-08-30

申请号：US10529923

申请日：2003-10-08

申请人： Alicia Santos Savio ,  Ricardo Silva Rodriguez ,  Yanelis Morera Diaz ,  Armando Alexei Rodriquez Alfonso ,  Jose Rafael Martinez Castillo ,  Haydee Geronimo Perez ,  Alejandro Moro Soria ,  Silvio Ernesto Perea Rodriguez

发明人： Alicia Santos Savio ,  Ricardo Silva Rodriguez ,  Yanelis Morera Diaz ,  Armando Alexei Rodriquez Alfonso ,  Jose Rafael Martinez Castillo ,  Haydee Geronimo Perez ,  Alejandro Moro Soria ,  Silvio Ernesto Perea Rodriguez

IPC分类号： A61K38/20

CPC分类号： A61K39/0005

摘要： Vaccine composition containing IL-15 for active immunization to treatment diseases related to over-expression of this cytokine. The technical aim pursued in this invention is to inhibit IL-15 activity through development of a therapeutic vaccine which elicits IL-15 neutralizing antibodies in the immunized host.IL-15 can be presented in this vaccine composition either alone or coupled to a carrier such as the P64k protein with a vaccine adjuvant such as Aluminum hydroxide.Besides, this invention is related to the use of this vaccine for treatment of Rheumatoid arthritis and other IL-15 over-expressing related diseases, and leukemia, where this cytokine acts as a growth factor.

摘要翻译： 含有IL-15的疫苗组合物用于主动免疫治疗与该细胞因子的过表达有关的疾病。 在本发明中追求的技术目的是通过开发在免疫宿主中引发IL-15中和抗体的治疗性疫苗来抑制IL-15活性。 IL-15可以单独存在于该疫苗组合物中，也可以与诸如氢氧化铝等疫苗佐剂的载体例如P64k蛋白偶联。 此外，本发明涉及该疫苗用于治疗类风湿性关节炎和其它IL-15过表达相关疾病和白血病，其中该细胞因子作为生长因子。