公开(公告)号：US20110071099A1

公开(公告)日：2011-03-24

申请号：US11666518

申请日：2005-10-31

申请人： Alicja Bielawska ,  Zdzislaw M. Szuic ,  Yusuf A. Hannun ,  Lina M. Obeid ,  Besim Ogretmen

发明人： Alicja Bielawska ,  Zdzislaw M. Szuic ,  Yusuf A. Hannun ,  Lina M. Obeid ,  Besim Ogretmen

IPC分类号： A61K31/704 ,  A61K31/133 ,  C07C215/06 ,  C07D213/04 ,  A61P35/00 ,  C12N5/06 ,  A61K31/4425 ,  A61K31/513

CPC分类号： C07D213/56

摘要： The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.

摘要翻译： 本发明涉及阳离子神经酰胺，其二氢类似物和芳族类似物及其衍生物，其包含吡啶鎓基团。 还提供了制备包含吡啶鎓基团的阳离子神经酰胺的方法及其用于治疗或预防与细胞过度增殖和鞘脂信号转导相关的疾病如癌症，炎症和狭窄的用途。 该化合物也可用作线粒体药物，其被定位于与其携带化学货物的线粒体，例如药物或信号分子，例如用于探测细胞器结构和功能的荧光团。

公开(公告)号：US08093393B2

公开(公告)日：2012-01-10

申请号：US11666518

申请日：2005-10-31

申请人： Alicja Bielawska ,  Zdzislaw M. Szulc ,  Yusuf A. Hannun ,  Lina M. Obeid ,  Besim Ogretmen

发明人： Alicja Bielawska ,  Zdzislaw M. Szulc ,  Yusuf A. Hannun ,  Lina M. Obeid ,  Besim Ogretmen

IPC分类号： C07D211/00 ,  C07D211/92

CPC分类号： C07D213/56

摘要： The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.

摘要翻译： 本发明涉及阳离子神经酰胺，其二氢类似物和芳族类似物及其衍生物，其包含吡啶鎓基团。 还提供了制备包含吡啶鎓基团的阳离子神经酰胺的方法及其用于治疗或预防与细胞过度增殖和鞘脂信号转导相关的疾病如癌症，炎症和狭窄的用途。 该化合物也可用作线粒体药物，其被定位于与其携带化学货物的线粒体，例如药物或信号分子，例如用于探测细胞器结构和功能的荧光团。