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1.发明申请TNFalpha GENE EXPRESSION AS A BIOMARKER OF SENSITIVITY TO ANTAGONISTS OF INHIBITOR OF APOPTOSIS PROTEINS 审中-公开TNFα基因表达作为敏感性生物标志物对抗病毒蛋白抑制剂的拮抗作用公开(公告)号：US20110008802A1
公开(公告)日：2011-01-13
申请号：US12598940
申请日：2008-05-07
申请人： Alireza Alavi , Mark A. McKinlay , Srinivas K. Chunduru , John Silke , David Vaux , James Vince
发明人： Alireza Alavi , Mark A. McKinlay , Srinivas K. Chunduru , John Silke , David Vaux , James Vince
IPC分类号： G01N33/53
CPC分类号： G01N33/6863 , A61K31/40 , G01N2333/525
摘要： TNFα gene expression can be used as a biomarker of a cell's sensitivity to antagonists of inhibitor of apoptosis proteins (IAPs). Methods of the invention are useful for screening patients to identify those who could benefit from administration of an IAP antagonist to treat various malignant or benign tumors, benign proliferative diseases, or autoimmune diseases.
摘要翻译： TNFα基因表达可用作细胞对凋亡蛋白抑制剂（IAP）的拮抗剂的敏感性的生物标志物。 本发明的方法可用于筛选患者以鉴定可以从施用IAP拮抗剂受益于治疗各种恶性或良性肿瘤，良性增殖性疾病或自身免疫疾病的那些患者。
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公开(公告)号：US20130273036A1
公开(公告)日：2013-10-17
申请号：US13851153
申请日：2013-03-27
IPC分类号： C07K16/22
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
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公开(公告)号：US09006397B2
公开(公告)日：2015-04-14
申请号：US13851153
申请日：2013-03-27
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/22 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.
摘要翻译： 本公开提供了包含结合Fn14的抗体抗原结合结构域的蛋白质及其用途。 本公开还提供了治疗诸如恶病质之类的消耗性疾病的方法。
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