公开(公告)号：US20210275691A1

公开(公告)日：2021-09-09

申请号：US17058037

申请日：2019-05-30

申请人： Allergan, Inc.

发明人： Jie Shen ,  Hsiang Ho ,  Lydia Andrew-Jones ,  Betsy Bloom ,  Greg Nicholson ,  Lance Steward ,  Amy Brideau-Anderson ,  Terrence Hunt ,  Ron Broide ,  David Rupp ,  David Canty

IPC分类号： A61K49/00 ,  G01N33/50 ,  A61K9/00

摘要： An in vivo assay to evaluate topical delivery of a biologic agent from a formulation is provided. The assay comprises treating a skin area of a CD hairless rat with tape stripping to disrupt the stratum corneum in the skin area to define a treated skin area and topically applying a formulation to the treated skin area. The formulation, in one embodiment, comprises the biologic agent and a pharmaceutically acceptable carrier. Delivery of the biologic agent into the skin from the topically applied formulation is evaluated via in vitro or in vivo techniques.