公开(公告)号：US20220160937A1

公开(公告)日：2022-05-26

申请号：US17649989

申请日：2022-02-04

申请人： AlloSource

发明人： Matthew James Southard ,  Adrian C. Samaniego ,  Kenneth Blood ,  Marina Katelyn Bull ,  Reginald Stilwell ,  Carolyn Barrett Rorick ,  Matthew Peterson ,  Jan Zajdowicz ,  Arthur Joslyn ,  Kathryn Hanzlicek

IPC分类号： A61L27/36

摘要： Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and methods. The methods involve combining tissue with a processing solution in a processing vessel and applying resonant acoustic energy thereto. In some instances, the tissue is processed in the absence of processing solution. The resonant acoustic energy rapidly agitates the tissue with the processing solution by vibration. The general method provided is broadly applicable to a variety of tissue processing methods, the processing solution and features of the resonant acoustic energy being selected based on the type of tissue to be processed and the nature of the processing to be performed. Exemplary methods include methods of bone demineralization, tissue decellularization, tissue cryopreservation, production of stromal vascular fraction, tissue homogenization, tissue cleansing, and tissue decontamination, and assessment of microbial load. By applying resonant acoustic energy to the tissue during processing, the rate or efficiency of processing, or both, may be improved.

公开(公告)号：US20180280575A1

公开(公告)日：2018-10-04

申请号：US15995320

申请日：2018-06-01

申请人： AlloSource

发明人： Ryan Delaney ,  Matthew James Southard ,  Adrian C. Samaniego ,  Kenneth Blood ,  Marina Katelyn Bull ,  Reginald Stilwell ,  Carolyn Barrett Rorick ,  Matthew Peterson ,  Jan Zajdowicz ,  Arthur Joslyn ,  Kathryn Hanzlicek

IPC分类号： A61L27/36 ,  C12M3/00 ,  C12M1/42 ,  C12M1/33 ,  A61F2/30

摘要： Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and methods. Also provided are ball mill processing devices and systems useful for processing materials such as tissue. The methods involve combining tissue with or without a processing solution in a processing vessel and applying resonant acoustic energy thereto. The resonant acoustic energy rapidly agitates the tissue with the processing solution by vibration, thereby improving the rate and/or efficiency of processing. The general method provided is broadly applicable to a variety of tissue processing methods, the processing solution and features of the resonant acoustic energy being selected based on the type of tissue to be processed and the nature of the processing to be performed. Exemplary methods include methods of bone demineralization, tissue decellularization, tissue cryopreservation, production of stromal vascular fraction, tissue fragmentation, tissue cleansing, and tissue decontamination, and assessment of microbial load.

公开(公告)号：US20170035937A1

公开(公告)日：2017-02-09

申请号：US15231586

申请日：2016-08-08

申请人： AlloSource

发明人： Matthew James Southard ,  Adrian C. Samaniego ,  Kenneth Blood ,  Marina Katelyn Bull ,  Reginald Stilwell ,  Carolyn Barrett ,  Matthew Peterson ,  Jan Zajdowicz ,  Arthur Joslyn ,  Kathryn Hanzlicek

IPC分类号： A61L27/36

CPC分类号： A61L27/3691 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/362 ,  A61L27/3683 ,  A61L2430/02

摘要： Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and methods. The methods involve combining tissue with a processing solution in a processing vessel and applying resonant acoustic energy thereto. In some instances, the tissue is processed in the absence of processing solution. The resonant acoustic energy rapidly agitates the tissue with the processing solution by vibration. The general method provided is broadly applicable to a variety of tissue processing methods, the processing solution and features of the resonant acoustic energy being selected based on the type of tissue to be processed and the nature of the processing to be performed. Exemplary methods include methods of bone demineralization, tissue decellularization, tissue cryopreservation, production of stromal vascular fraction, tissue homogenization, tissue cleansing, and tissue decontamination, and assessment of microbial load. By applying resonant acoustic energy to the tissue during processing, the rate or efficiency of processing, or both, may be improved.

摘要翻译： 提供了用于治疗或处理组织的系统和方法，以及使用这种系统和方法制备的组织产品。 所述方法包括将组织与处理容器中的处理溶液组合并向其施加共振声能。 在一些情况下，在没有处理溶液的情况下处理组织。 共振声能通过振动迅速地搅动处理溶液的组织。 提供的一般方法广泛地适用于各种组织处理方法，基于要处理的组织的类型和要执行的处理的性质来选择共振声能的处理方案和特征。 示例性方法包括骨脱矿质，组织脱细胞化，组织冷冻保存，基质血管部分的产生，组织匀浆，组织清洁和组织去污以及微生物负荷评估的方法。 通过在处理期间向组织施加共振声能，可以提高加工速度或效率，或两者。