公开(公告)号：US20230407252A1

公开(公告)日：2023-12-21

申请号：US18308797

申请日：2023-04-28

Applicant: Allogene Therapeutics, Inc.

Inventor： Meng-Yin LIN ,  Hayung YOON ,  Thomas Charles PERTEL ,  Barbra Johnson SASU

IPC: C12N5/0783 ,  C07K14/725

CPC classification number: C12N5/0636 ,  C07K14/7051 ,  C12N2510/00 ,  C07K2319/03 ,  C07K2319/02

Abstract: Provided herein are methods, kits and reagents for analyzing the attributes of cell populations, such as donor cells prior to modification to provide engineered cells, e.g., engineered immune cells, such as CAR T cells. For example, provided herein are methods of determining the amount or percentage of biomarkers and/or secretion profiles of donor cell populations, selecting donor cells with certain biomarkers and/or secretion profiles, and engineering the CAR T cells from the selected donor cells.