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公开(公告)号：US10208307B2
公开(公告)日：2019-02-19
申请号：US15221651
申请日：2016-07-28
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113
摘要： The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated diseases.
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2.发明申请公开(公告)号：US20200377889A1
公开(公告)日：2020-12-03
申请号：US16864226
申请日：2020-05-01
IPC分类号： C12N15/113
摘要： The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated diseases.
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公开(公告)号：US11286486B2
公开(公告)日：2022-03-29
申请号：US16864226
申请日：2020-05-01
IPC分类号： C12N15/113 , A61K31/713 , A61K31/7125
摘要： The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated diseases.
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公开(公告)号：US10683501B2
公开(公告)日：2020-06-16
申请号：US16223362
申请日：2018-12-18
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113
摘要： The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated diseases.
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公开(公告)号：US20230022185A1
公开(公告)日：2023-01-26
申请号：US17584463
申请日：2022-01-26
IPC分类号： C12N15/113
摘要： The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated diseases.
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6.发明申请TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES 审中-公开TRANSTHYRETIN（TTR）iRNA组合物及其用于治疗或预防TTR相关疾病的方法公开(公告)号：US20170029817A1
公开(公告)日：2017-02-02
申请号：US15221651
申请日：2016-07-28
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3515 , C12N2310/3533 , C12N2320/30
摘要： The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated diseases.
摘要翻译： 本发明提供靶向转甲状腺素蛋白（TTR）基因的iRNA试剂，例如双链iRNA试剂，以及使用这种iRNA试剂治疗或预防TTR相关疾病的方法。
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公开(公告)号：US12049628B2
公开(公告)日：2024-07-30
申请号：US17584463
申请日：2022-01-26
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3515 , C12N2310/3533 , C12N2320/30 , C12N2310/322 , C12N2310/3533
摘要： The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated diseases.
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8.发明公开公开(公告)号：US20240100080A1
公开(公告)日：2024-03-28
申请号：US18299220
申请日：2023-04-12
发明人： Amy Chan , John Vest , Gabriel Robbie , Husain Z. Attarwala , Varun Goel
IPC分类号： A61K31/713 , A61K31/7105 , C12N15/113
CPC分类号： A61K31/713 , A61K31/7105 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/322 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2310/3521 , C12N2310/3533 , C12N2320/31 , C12N2320/35
摘要： The present invention provides methods for treating or preventing TTR-associated diseases using RNAi agents, e.g., double stranded RNAi agents, that target the transthyretin (TTR) gene.
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9.发明申请公开(公告)号：US20190350962A1
公开(公告)日：2019-11-21
申请号：US16468953
申请日：2017-12-15
发明人： Amy Chan , John Vest , Gabriel Robbie , Husain Z. Attarwala , Varun Goel
IPC分类号： A61K31/713 , C12N15/113 , A61K31/7105
摘要： The present invention provides methods for treating or preventing TTR-associated diseases using RNAi agents, e.g., double stranded RNAi agents, that target the transthyretin (TTR) gene.
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