公开(公告)号：US4834919A

公开(公告)日：1989-05-30

申请号：US868

申请日：1987-01-06

申请人： Ambrogio Magni ,  Oreste Piccolo ,  Antonio Ascheri

发明人： Ambrogio Magni ,  Oreste Piccolo ,  Antonio Ascheri

IPC分类号： C07J9/00

CPC分类号： C07J9/005

摘要： The keto group at the 7-position of a bile keto acid is stereoselectively reduced to a beta-hydroxy group with hydrogen in the presence of nickel, a base (the quantity of which is at least 0.3 mole for each mole of keto acid), and an alcohol having from 3 to 10 C atoms, selected from the group consisting of secondary alcohols, tertiary alcohols and beta-branched alcohols.

摘要翻译： 在镍的存在下，将胆酸酮酸的7位上的酮基立体选择性地还原为β-羟基，碱（每摩尔酮酸为至少0.3摩尔）， 和具有3至10个C原子的醇，其选自仲醇，叔醇和β-支链醇。