公开(公告)号：US06890738B2

公开(公告)日：2005-05-10

申请号：US09065330

申请日：1998-04-23

申请人： Ameae Walker

发明人： Ameae Walker

IPC分类号： A61K38/00 ,  C07K14/575 ,  C12N1/21 ,  A61K38/22 ,  C12N15/16 ,  C12N15/63

CPC分类号： C07K14/57554 ,  A61K38/00 ,  C07K2319/00

摘要： Recombinant nucleotide sequences encoding mutated prolactin are described. Expression of the sequences result in mimics of a phosphorylated prolactin corresponding to a selected species. A particularly preferred mimic is mutated at serine 179 (corresponding to human PRL) where serine is substituted by an aspartate residue. This aspartate mutant is a very effective antagonist and shows no ability to stimulate Nb2 to cell proliferation.

摘要翻译： 描述了编码突变催乳素的重组核苷酸序列。 序列的表达导致对应于所选物种的磷酸化催乳素的模拟。 特别优选的模拟物在丝氨酸179（相当于人PRL）突变，丝氨酸被天冬氨酸残基取代。 这种天冬氨酸突变体是非常有效的拮抗剂，并且不显示刺激Nb2对细胞增殖的能力。