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公开(公告)号：US20200024319A1
公开(公告)日：2020-01-23
申请号：US15565376
申请日：2016-05-04
Applicant: AMGEN INC. , Amgen Inc.
Inventor： Eric Alan BUTZ , Christy Ann THOMSON , Marc Alain GAVIN , Ian Nevin FOLTZ , Dong XIA , Dina N. ALCORN , Ai Ching LIM , Randal Robert KETCHUM , Kathy MANCHULENKO , Laura SEKIROV , Kelly Ann BERRY , Cyr Clovis Chua DE IMUS , Neeraj Jagdish AGRAWAL , Gunasekaran KANNAN , Li LI
Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.
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公开(公告)号：US20240327486A1
公开(公告)日：2024-10-03
申请号：US18627761
申请日：2024-04-05
Applicant: Amgen Inc.
Inventor： Eric Alan BUTZ , Christy Ann THOMSON , Marc Alain GAVIN , Ian Nevin FOLTZ , Dong XIA , Dina N. ALCORN , Randal Robert KETCHEM , Ai Ching LIM , Kathy MANCHULENKO , Laura SEKIROV , Kelly Ann BERRY , Cyr Clovis Chua DE IMUS , Neeraj Jagdish AGRAWAL , Gunasekaran KANNAN , Li LI
CPC classification number: C07K14/55 , A61K38/2013 , A61P37/00 , C07K16/246 , C07K2317/21 , C07K2317/41 , C07K2317/524 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30
Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.
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公开(公告)号：US20240368292A1
公开(公告)日：2024-11-07
申请号：US18611364
申请日：2024-03-20
Applicant: Amgen Inc.
Inventor： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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公开(公告)号：US20220119537A1
公开(公告)日：2022-04-21
申请号：US17339301
申请日：2021-06-04
Applicant: Amgen Inc.
Inventor： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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公开(公告)号：US20210139554A1
公开(公告)日：2021-05-13
申请号：US17065395
申请日：2020-10-07
Applicant: Amgen Inc.
Inventor： Eric Alan BUTZ , Christy Ann THOMSON , Marc Alain GAVIN , Ian Nevin FOLTZ , Dong XIA , Dina N. ALCORN , Randal Robert KETCHEM , Ai Ching LIM , Kathy MANCHULENKO , Laura SEKIROV , Kelly Ann BERRY , Cyr Clovis Chua DE IMUS , Neeraj Jagdish AGRAWAL , Gunasekaran KANNAN , Li LI
Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.
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Patent Agency Ranking
公开(公告)号：US20170267769A1
公开(公告)日：2017-09-21
申请号：US15601868
申请日：2017-05-22
Applicant: Amgen Inc.
Inventor： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
IPC: C07K16/28
CPC classification number: C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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公开(公告)号：US20140004107A1
公开(公告)日：2014-01-02
申请号：US13897096
申请日：2013-05-17
Applicant: Amgen Inc.
Inventor： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
CPC classification number: C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
Abstract translation: 本文描述的是与抗原结合蛋白相关的组合物和方法，其结合人ST2，包括抗体。 在具体实施方案中，本公开提供完全人抗-ST2抗体及其衍生物及其变体。 还提供了编码这种抗体和抗体片段，变体和衍生物的核酸。 此外，提供制备和使用这些抗体的方法，包括治疗和预防自身免疫性和炎症性疾病的方法。
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公开(公告)号：US20170002079A1
公开(公告)日：2017-01-05
申请号：US15178652
申请日：2016-06-10
Applicant: Amgen Inc.
Inventor： Dirk E. SMITH , Ian FOLTZ , Chadwick T. KING , Ai Ching LIM , Rutilio CLARK , Michael R. COMEAU , Randal R. KETCHEM , Donghui SHI , Xiaoshan MIN , Zhulun WANG
IPC: C07K16/28
CPC classification number: C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
Abstract translation: 本文描述的是与抗原结合蛋白相关的组合物和方法，其结合人ST2，包括抗体。 在具体实施方案中，本公开提供完全人抗-ST2抗体及其衍生物及其变体。 还提供了编码这种抗体和抗体片段，变体和衍生物的核酸。 此外，提供制备和使用这些抗体的方法，包括治疗和预防自身免疫性和炎症性疾病的方法。
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9.发明申请公开(公告)号：US20160176971A1
公开(公告)日：2016-06-23
申请号：US15058104
申请日：2016-03-01
Applicant: Amgen Inc.
Inventor： Marc A. GAVIN , Ai Ching LIM
IPC: C07K16/28 , A61K45/06 , A61K39/395
CPC classification number: C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides compositions and methods relating to antigen binding proteins against IL-21 receptor.
Abstract translation: 本发明提供了与针对IL-21受体的抗原结合蛋白有关的组合物和方法。
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10.发明申请公开(公告)号：US20140105900A1
公开(公告)日：2014-04-17
申请号：US13830844
申请日：2013-03-14
Applicant: AMGEN INC.
Inventor： Marc A. GAVIN , Ai Ching LIM
IPC: C07K16/28 , A61K45/06 , A61K39/395
CPC classification number: C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides compositions and methods relating to antigen binding proteins against IL-21 receptor.
Abstract translation: 本发明提供了与针对IL-21受体的抗原结合蛋白有关的组合物和方法。
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