公开(公告)号：US11078288B2

公开(公告)日：2021-08-03

申请号：US15955304

申请日：2018-04-17

Applicant: Amgen Inc.

Inventor： Pedro J. Beltran ,  Frank J. Calzone ,  Gregory Friberg ,  Christopher Haqq ,  Anthony W. Tolcher

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K39/00

Abstract: The present invention provides, in part, methods for treating a tumor in a human subject comprising inhibiting IGF-1 receptor signaling, methods of determining whether a tumor is more or less likely to respond to such treatment, and compositions for practicing such methods. In particular embodiments, the invention provides fully human, humanized, or chimeric anti-IGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments and derivatives of such antibodies, and IGF-1R-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having IGF-1R-related disorders or conditions.

公开(公告)号：US08921367B2

公开(公告)日：2014-12-30

申请号：US13906231

申请日：2013-05-30

Applicant: Amgen Inc.

Inventor： Gregory Friberg ,  Marc Payton

IPC: A61K31/506 ,  A61K38/19 ,  A61K45/06

CPC classification number: A61K31/506 ,  A61K38/193 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to methods of using AMG 900, a small molecule pan aurora kinase inhibitor, for the treatment of cancer, including solid tumors, hematologically derived tumors and the like. The invention further provides pharmaceutical compositions, dosage ranges and treatment regimens for administering AMG 900 to treat cancer.

Abstract translation: 本发明涉及使用AMG 900，一种小分子泛极光激酶抑制剂，用于治疗癌症，包括实体瘤，血液衍生的肿瘤等。 本发明还提供了用于施用AMG 900以治疗癌症的药物组合物，剂量范围和治疗方案。