公开(公告)号：US20150056204A1

公开(公告)日：2015-02-26

申请号：US14388762

申请日：2013-03-27

Applicant: Amgen Inc.

Inventor： Pamela Mary Holland ,  Jonathan David Graves ,  Jennifer Joy Kordich ,  Julia Catherine Piasecki ,  Ian Nevin Foltz

IPC: C07K16/28 ,  A61K38/19 ,  A61K39/395

CPC classification number: C07K16/2878 ,  A61K38/191 ,  A61K39/39541 ,  A61K39/3955 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/30 ,  C07K2317/41 ,  C07K2317/71 ,  C07K2317/73 ,  A61K2300/00

Abstract: The present invention includes apoptotic compositions and methods for inducing apoptosis of cancer cells independent of NK cells. An apoptotic composition comprises a cooperative combination of antibodies that specifically bind to human DR5, or a cooperative combination of an anti-DR5 antibody and TRAIL. Administration of therapeutically effective amounts of an apoptotic composition induces apoptosis of apoptosis sensitive cancer cells.

Abstract translation: 本发明包括凋亡组合物和诱导与NK细胞无关的癌细胞凋亡的方法。 凋亡组合物包含与人DR5特异性结合的抗体或抗DR5抗体和TRAIL的协同组合的协同组合。 施用治疗有效量的凋亡组合物诱导凋亡敏感性癌细胞的凋亡。

公开(公告)号：US20190284290A1

公开(公告)日：2019-09-19

申请号：US16176343

申请日：2018-10-31

Applicant: Amgen Inc.

Inventor： Pamela Mary Holland ,  Jonathan David Graves ,  Jennifer Joy Kordich ,  Julia Catherine Piasecki ,  Ian Nevin Foltz

IPC: C07K16/28 ,  A61K39/395 ,  A61K38/19

Abstract: The present invention includes apoptotic compositions and methods for inducing apoptosis of cancer cells independent of NK cells. An apoptotic composition comprises a cooperative combination of antibodies that specifically bind to human DR5, or a cooperative combination of an anti-DR5 antibody and TRAIL. Administration of therapeutically effective amounts of an apoptotic composition induces apoptosis of apoptosis sensitive cancer cells.