公开(公告)号：US12054527B2

公开(公告)日：2024-08-06

申请号：US16620029

申请日：2019-04-08

申请人： Amgen Inc.

发明人： YuMei Xiong ,  Kenneth William Walker ,  Murielle Marie Veniant Ellison

IPC分类号： C07K14/495 ,  A61K38/00

CPC分类号： C07K14/495 ,  A61K38/00 ,  C07K2319/30

摘要： GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.

公开(公告)号：US11161889B2

公开(公告)日：2021-11-02

申请号：US17148761

申请日：2021-01-14

申请人： Amgen Inc.

发明人： YuMei Xiong ,  Kenneth William Walker ,  Murielle Marie Veniant Ellison

IPC分类号： C07K14/495

摘要： GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.