公开(公告)号：US11053226B2

公开(公告)日：2021-07-06

申请号：US16687546

申请日：2019-11-18

申请人： Amgen Inc.

发明人： Youngsook Shin ,  Victor J. Cee ,  Christopher M. Tegley ,  Brian Alan Lanman ,  Ryan Paul Wurz ,  Kevin C. Yang ,  Vu Van Ma ,  Daniel Erlanson ,  Joon Won Jeong ,  Raymond V. Fucini ,  Jeffrey Iwig

IPC分类号： C07D403/14 ,  C07D401/14 ,  C07D403/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61P35/00

摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.