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1.发明申请Treatment of Eye Disorders Characterized by an Elevated Intraocular Pressure by siRNAs 有权通过siRNA升高的眼内压治疗眼部疾病公开(公告)号：US20070270365A1
公开(公告)日：2007-11-22
申请号：US11574169
申请日：2005-08-23
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： Sequences and protocols for treatment of eye conditions by use of RNA interference are disclosed. Target genes are selected from those responsible for aqueous flow or aqueous outflow, while particularly preferred conditions to be treated include glaucoma and uveitis.
摘要翻译： 公开了通过使用RNA干扰治疗眼睛状况的序列和方案。 靶基因选自负责水流或水流出的那些，而待治疗的特别优选的病症包括青光眼和葡萄膜炎。
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2.发明申请公开(公告)号：US20060234970A1
公开(公告)日：2006-10-19
申请号：US11360305
申请日：2006-02-22
申请人： Ana Jimenez , Angela Sesto , Irene Gascon , Jose Roman
发明人： Ana Jimenez , Angela Sesto , Irene Gascon , Jose Roman
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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