公开(公告)号：US20100041665A1

公开(公告)日：2010-02-18

申请号：US12375614

申请日：2007-08-01

申请人： Ana Martinez Gil ,  Ana Castro Morera ,  Miguel Medina Padilla ,  Pilar Munoz Ruiz ,  Javier Lopez Ogalla ,  Esther Garcia Palomero ,  Celia De Austria De Luque ,  Paola Usan Egea ,  Rita Valenzuela Liminana ,  Pablo Garcia Fernandez ,  Elena Delgado Hernandez ,  Daniel Ignacio Perez Fernandez

发明人： Ana Martinez Gil ,  Ana Castro Morera ,  Miguel Medina Padilla ,  Pilar Munoz Ruiz ,  Javier Lopez Ogalla ,  Esther Garcia Palomero ,  Celia De Austria De Luque ,  Paola Usan Egea ,  Rita Valenzuela Liminana ,  Pablo Garcia Fernandez ,  Elena Delgado Hernandez ,  Daniel Ignacio Perez Fernandez

IPC分类号： A61K31/4965 ,  C07C229/34 ,  C07C63/64 ,  C07D315/00 ,  C07D241/04 ,  C07D231/02 ,  A61K31/24 ,  A61K31/19 ,  A61K31/351 ,  A61K31/415 ,  A61P25/28 ,  A61P21/00 ,  A61P25/18 ,  A61P9/10

CPC分类号： C07C229/64 ,  C07C211/48 ,  C07C217/84 ,  C07C229/60 ,  C07C231/12 ,  C07C237/44 ,  C07C271/28 ,  C07C279/22 ,  C07D231/14 ,  C07D233/64 ,  C07D295/192 ,  C07D309/12

摘要： The present invention is related to a family of N-phenyl-prenylamine derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.

摘要翻译： 本发明涉及式（I）的N-苯基 - 异戊胺衍生物家族及其在治疗认知，神经变性或神经元疾病或病症如阿尔茨海默氏病或​​帕金森病中的用途。 本发明还涉及包含其的药物组合物。 此外，本发明涉及该化合物在制备用于治疗和/或预防认知，神经变性或神经元疾病或病症的药物中的用途。

公开(公告)号：US20100267827A1

公开(公告)日：2010-10-21

申请号：US12375607

申请日：2007-08-01

申请人： Ana Martinez Gil ,  Ana Castro Morera ,  Miguel Medina Padilla ,  Pilar Munoz Ruiz ,  Javier Lopez Ogalla ,  Laura Rubio Arrieta ,  Esther Garcia Palomero ,  Pablo Garcia Fernandez ,  Celia De Austria De Luque ,  Elena Delgado Hernandez ,  Paola Usan Egea ,  Rita Valenzuela Liminana ,  Jorge Sanchez-Quesada

发明人： Ana Martinez Gil ,  Ana Castro Morera ,  Miguel Medina Padilla ,  Pilar Munoz Ruiz ,  Javier Lopez Ogalla ,  Laura Rubio Arrieta ,  Esther Garcia Palomero ,  Pablo Garcia Fernandez ,  Celia De Austria De Luque ,  Elena Delgado Hernandez ,  Paola Usan Egea ,  Rita Valenzuela Liminana ,  Jorge Sanchez-Quesada

IPC分类号： A61K31/245 ,  C07C69/92 ,  A61K31/235 ,  A61P25/28 ,  A61P25/16 ,  A61P25/24 ,  A61P25/08 ,  A61P25/18 ,  A61P9/10 ,  C07C43/215 ,  A61K31/085 ,  C07C65/21 ,  A61K31/192 ,  C07C229/64 ,  C07C235/46 ,  A61K31/166 ,  A61K31/196

CPC分类号： C07C235/46 ,  C07C43/215 ,  C07C65/28 ,  C07C69/92 ,  C07C229/60 ,  C07C233/54

摘要： The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or 5 Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.

摘要翻译： 本发明涉及式（I）的苯基 - 异戊烯基醚衍生物及其在治疗认知，神经变性或神经元疾病或病症如阿尔茨海默病或5帕金森病中的用途。 本发明还涉及包含其的药物组合物。 此外，本发明涉及该化合物在制备用于治疗和/或预防认知，神经变性或神经元疾病或病症的药物中的用途。