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    Compositions and methods for enhancing contrast in imaging
    1.
    发明授权
    Compositions and methods for enhancing contrast in imaging 有权
    用于增强成像对比度的组合和方法

    公开(公告)号：US07713517B2

    公开(公告)日：2010-05-11

    申请号：US10830190

    申请日：2004-04-21

    申请人： Ananth Annapragada ,  Ravi V. Bellamkonda ,  Eric Hoffman ,  Chandra Vijayalakshmi

    发明人： Ananth Annapragada ,  Ravi V. Bellamkonda ,  Eric Hoffman ,  Chandra Vijayalakshmi

    IPC分类号： A61K8/00 ,  A61K9/00 ,  A61K49/04

    CPC分类号： A61K49/0093 ,  A61K9/1271 ,  A61K49/0438 ,  A61K49/0466

    摘要： Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.

    摘要翻译： 提供了具有在其表面上具有亲水性聚合物并含有相对高浓度的用于计算机断层摄影的对比度增强剂的脂质体的实例组合物。 当向受试者施用时，这种脂质体的示例药物组合物通过计算机断层摄影在受试者的血流和其他组织中测量延长的持续时间的增强的对比度。 还提供了制备含有高浓度对比度增强剂的脂质体的实例方法，以及使用该组合物的实例方法。

    Compositions And Methods For Enhancing Contrast In Imaging
    3.
    发明申请
    Compositions And Methods For Enhancing Contrast In Imaging 审中-公开
    用于增强成像对比度的组合和方法

    公开(公告)号：US20080131369A1

    公开(公告)日：2008-06-05

    申请号：US11568936

    申请日：2005-01-12

    申请人： Ananth Annapragada ,  Ravi V. Bellamkonda ,  Eric Hoffman ,  Chandra Vijayalakshmi ,  Chen-Yu Kao ,  Ketan Ghaghada

    发明人： Ananth Annapragada ,  Ravi V. Bellamkonda ,  Eric Hoffman ,  Chandra Vijayalakshmi ,  Chen-Yu Kao ,  Ketan Ghaghada

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0093 ,  A61K9/1271 ,  A61K49/0438 ,  A61K49/0466

    摘要： Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.

    摘要翻译： 提供了具有在其表面上具有亲水性聚合物并含有相对高浓度的用于计算机断层摄影的对比度增强剂的脂质体的实例组合物。 当向受试者施用时，这种脂质体的示例药物组合物通过计算机断层摄影在受试者的血流和其他组织中测量延长的持续时间的增强的对比度。 还提供了制备含有高浓度对比度增强剂的脂质体的实例方法，以及使用该组合物的实例方法。

    DEVICES, SYSTEMS, AND METHODS FOR EXCAVATING CANCER CELLS
    8.
    发明申请
    DEVICES, SYSTEMS, AND METHODS FOR EXCAVATING CANCER CELLS 审中-公开
    用于排除癌细胞的装置，系统和方法

    公开(公告)号：US20130172846A1

    公开(公告)日：2013-07-04

    申请号：US13814009

    申请日：2011-08-04

    申请人： Ravi V. Bellamkonda ,  Anjana Jain

    发明人： Ravi V. Bellamkonda ,  Anjana Jain

    IPC分类号： A61M5/00

    CPC分类号： A61M5/00 ,  A61K9/0092 ,  A61K9/70 ,  A61K31/05 ,  A61K31/4355 ,  A61K31/443 ,  A61K31/704 ,  A61K47/34 ,  A61K47/593 ,  A61K47/6435 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2400/12 ,  C08L89/00 ,  C08L75/04 ,  C08L67/04

    摘要： Methods, devices, and systems are provided for guiding tumor movement, particularly in vivo for treatment of patients. The method may include implanting into a tissue site where tumor cells are present a device having one or more surface structures or substrates, such as aligned nanofibers, which provide physical guidance cues for directing the migration of the tumor cells from the first tissue location to a selected second location, for tumor cell extraction or death. The devices and systems may include a cytotoxic agent for contacting tumor cells migrated via the substrate. All or a portion of the at least one substrate may include one or more biochemical cues, such as a coating of laminin or another protein, which may be provided in a concentration gradient to facilitate uni-directional tumor cell migration.

    摘要翻译： 提供方法，装置和系统用于引导肿瘤移动，特别是用于治疗患者的体内。 该方法可以包括植入组织部位，其中肿瘤细胞存在具有一个或多个表面结构或底物的装置，例如排列的纳米纤维，其提供用于引导肿瘤细胞从第一组织位置迁移到 选择第二个位置，用于肿瘤细胞提取或死亡。 所述装置和系统可包括用于接触通过底物迁移的肿瘤细胞的细胞毒性剂。 至少一个底物的全部或一部分可以包括一种或多种生物化学提示，例如层粘连蛋白或另一种蛋白质的包衣，其可以浓度梯度提供以促进单向肿瘤细胞迁移。

    NANOCARRIER THERAPY FOR TREATING INVASIVE TUMORS
    9.
    发明申请
    NANOCARRIER THERAPY FOR TREATING INVASIVE TUMORS 有权
    用于治疗侵袭性肿瘤的纳诺卡治疗

    公开(公告)号：US20120052115A1

    公开(公告)日：2012-03-01

    申请号：US13263257

    申请日：2010-04-21

    申请人： Jennifer M. Munson ,  Ravi V. Bellamkonda ,  Jack L. Arbiser

    发明人： Jennifer M. Munson ,  Ravi V. Bellamkonda ,  Jack L. Arbiser

    IPC分类号： A61K9/133 ,  A61P35/00 ,  A61K31/55 ,  B82Y5/00

    CPC分类号： A61K9/1271 ,  A61K9/0019 ,  A61K31/55 ,  A61K45/06

    摘要： Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis. The liposomes include cholesterol and chemically pure phospholipids that are essentially neutral and contain saturated fatty acids of between 16 and 18 carbon atoms, such as distearoylphosphatidyl choline, and can also include one or more pegylated phospholipids, such as DSPE-PEG.

    摘要翻译： 尺寸小于200纳米的脂质体靶向肿瘤，并优先向肿瘤（包括脑肿瘤如胶质瘤）递送丙咪嗪蓝。 丙咪嗪蓝降低肿瘤的侵袭性，并抑制肿瘤转移。 脂质体包括基本上是中性的含有16-18个碳原子的饱和脂肪酸的胆固醇和化学纯的磷脂，例如二硬脂酰磷脂酰胆碱，还可以包括一种或多种聚乙二醇化磷脂，例如DSPE-PEG。