公开(公告)号：US20120046231A1

公开(公告)日：2012-02-23

申请号：US13215473

申请日：2011-08-23

申请人： Andre Francis Palmer ,  Pedro Cabrales

发明人： Andre Francis Palmer ,  Pedro Cabrales

IPC分类号： A61K38/38 ,  A61P7/00 ,  C07K14/765

CPC分类号： A61K38/38

摘要： Described herein is a composition and process for synthesizing a human serum albumin (HSA) based plasma replacement composition that includes a polymerized HSA (PolyHSA) that is chemically stabilized by the reduction of Schiff bases. The PolyHSA may have a molecular weight of at least about 100 kDa and may optionally have a cross-linker to HSA molar ratio of at least about 10:1. The PolyHSA composition is useful for restoring a subject's circulatory volume.

摘要翻译： 本文描述的是用于合成基于血浆白蛋白（HSA）的血浆置换组合物的组合物和方法，其包括通过还原希夫碱化学稳定的聚合的HSA（PolyHSA）。 PolyHSA可以具有至少约100kDa的分子量，并且可以任选地具有至少约10:1的HSA摩尔比的交联剂。 PolyHSA组合物可用于恢复受试者的循环体积。

公开(公告)号：US20120028899A1

公开(公告)日：2012-02-02

申请号：US12847868

申请日：2010-07-30

申请人： Andre Francis Palmer

发明人： Andre Francis Palmer

IPC分类号： A61K38/42 ,  C12N5/07 ,  A61P9/00 ,  C07K14/805

CPC分类号： C07K14/805 ,  A61K38/42

摘要： Described herein is a composition and process for synthesizing a hemoglobin-based oxygen carrier (HBOC) composition that includes a polymerized hemoglobin locked in at least one of the tense or relaxed quaternary state and has a molecular weight of at least about 500 kDa. The PolyHb may have a cross-linker to hemoglobin molar ratio of at least about 20:1. The polymerized hemoglobin is useful for delivering oxygen to cells, such as for treatment of anemic conditions in a subject, perfusion of tissues or organs, and supplementing cell culture media in cell culturing systems.

摘要翻译： 本文描述了一种用于合成基于血红蛋白的氧载体（HBOC）组合物的组合物和方法，其包含以至少一种紧密或松弛季状态锁定的分子量为至少约500kDa的聚合血红蛋白。 PolyHb可以具有至少约20:1的血红蛋白摩尔比的交联剂。 聚合的血红蛋白可用于将氧递送到细胞，例如用于治疗受试者的贫血状况，组织或器官的灌注，以及在细胞培养系统中补充细胞培养基。