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1.
公开(公告)号:US20100125064A1
公开(公告)日:2010-05-20
申请号:US12593721
申请日:2008-03-27
申请人: Andreas Boettcher , Nicole Buschmann , Pascal Furet , Jean-Marc Groell , Jorg Kallen , Joanna Hergovich Lisztwan , Keiichi Masuya , Lorenz Mayr , Andrea Vaupel
发明人: Andreas Boettcher , Nicole Buschmann , Pascal Furet , Jean-Marc Groell , Jorg Kallen , Joanna Hergovich Lisztwan , Keiichi Masuya , Lorenz Mayr , Andrea Vaupel
IPC分类号: A61K31/55 , C07D403/04 , C07D413/12 , C07D403/12 , C07D401/14 , A61K31/4178 , A61K31/497 , A61K31/5377 , A61P35/00
CPC分类号: C07D403/04
摘要: The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula I, wherein R1, R2, R3, R4, RA, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.
摘要翻译: 本发明涉及能够分别抑制p53或其变体和MDM2和/或MDM4或其变体之间的相互作用的3-杂环基吲哚基化合物,所述化合物具有式I,其中R 1,R 2,R 3,R 4, RA,Y和Y如说明书中所定义。 由于它们的活性,所述化合物可用于治疗由MDM2和/或MDM4或其变体如炎性或增殖性疾病或保护细胞的活性介导的各种疾病和疾病。
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2.
公开(公告)号:US08053457B2
公开(公告)日:2011-11-08
申请号:US12593721
申请日:2008-03-27
申请人: Andreas Boettcher , Nicole Buschmann , Pascal Furet , Jean-Marc Groell , Jorg Kallen , Joanna Hergovich Lisztwan , Keiichi Masuya , Lorenz Mayr , Andrea Vaupel
发明人: Andreas Boettcher , Nicole Buschmann , Pascal Furet , Jean-Marc Groell , Jorg Kallen , Joanna Hergovich Lisztwan , Keiichi Masuya , Lorenz Mayr , Andrea Vaupel
IPC分类号: A61K31/397 , A61K31/5377 , A61K31/496 , A61K31/506 , C07D401/14 , C07D403/14
CPC分类号: C07D403/04
摘要: The invention relates to 3-heterocyclyl indolyl compounds of formula I capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively: wherein R1, R2, R3, R4, RA, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.
摘要翻译: 本发明涉及能够分别抑制p53或其变体和MDM2和/或MDM4或其变体之间的相互作用的式I的3-杂环基吲哚基化合物:其中R1,R2,R3,R4,RA,Y和 Y如说明书中所定义。 由于它们的活性,所述化合物可用于治疗由MDM2和/或MDM4或其变体如炎性或增殖性疾病或保护细胞的活性介导的各种疾病和疾病。
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