公开(公告)号：US09855332B2

公开(公告)日：2018-01-02

申请号：US13476104

申请日：2012-05-21

申请人： Andrew F. Russo ,  Eric A. Kaiser ,  Ana Recober ,  Adisa Kuburas ,  Ann C. Raddant ,  Brian Robert Kovacevich ,  John A. Latham ,  Jeffrey T. L. Smith ,  Leon F. Garcia-Martinez

发明人： Andrew F. Russo ,  Eric A. Kaiser ,  Ana Recober ,  Adisa Kuburas ,  Ann C. Raddant ,  Brian Robert Kovacevich ,  John A. Latham ,  Jeffrey T. L. Smith ,  Leon F. Garcia-Martinez

IPC分类号： A61K45/06 ,  C07K16/26 ,  A61K39/00

CPC分类号： A61K45/06 ,  A61K2039/505 ,  C07K16/26 ,  C07K2317/24 ,  C07K2317/76

摘要： The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular the methods prevent or reduce diarrhea in conditions or treatments resulting in elevated CGRP levels, e.g., in the GI tract (colon) that are associated with diarrhea and/or improper electrolyte and fluid excretion from the bowel or urinary system. More specifically, this invention relates to treatments using the anti-CGRP antibodies and fragments described herein, and binding fragments thereof.

公开(公告)号：US09708393B2

公开(公告)日：2017-07-18

申请号：US13476632

申请日：2012-05-21

申请人： Andrew F. Russo ,  Eric A. Kaiser ,  Ana Recober ,  Adisa Kuburas ,  Ann C. Raddant ,  Brian Robert Kovacevich ,  John A. Latham ,  Jeffrey T. L. Smith ,  Leon F. Garcia-Martinez

发明人： Andrew F. Russo ,  Eric A. Kaiser ,  Ana Recober ,  Adisa Kuburas ,  Ann C. Raddant ,  Brian Robert Kovacevich ,  John A. Latham ,  Jeffrey T. L. Smith ,  Leon F. Garcia-Martinez

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/44 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61K2039/505 ,  Y02A50/383

摘要： The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like.

公开(公告)号：US20120294802A1

公开(公告)日：2012-11-22

申请号：US13476632

申请日：2012-05-21

申请人： Andrew F. Russo ,  Eric A. Kaiser ,  Ana Recober ,  Adisa Kuburas ,  Ann C. Raddant ,  Brian Robert Kovacevich ,  John A. Latham ,  Jeffrey T.L. Smith ,  Leon F. Garcia-Martinez

发明人： Andrew F. Russo ,  Eric A. Kaiser ,  Ana Recober ,  Adisa Kuburas ,  Ann C. Raddant ,  Brian Robert Kovacevich ,  John A. Latham ,  Jeffrey T.L. Smith ,  Leon F. Garcia-Martinez

IPC分类号： A61K39/395 ,  A61K51/10 ,  A61P25/06 ,  A61P25/00 ,  A61P27/02 ,  A61P27/12 ,  A61P13/00 ,  A61P35/00 ,  A61P31/16 ,  A61P31/04 ,  A61P3/00 ,  A61P31/12 ,  A61P25/24 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P15/00 ,  A61P19/10 ,  A61K49/00

CPC分类号： C07K16/18 ,  A61K2039/505 ,  Y02A50/383

摘要： The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like.

摘要翻译： 本发明涉及使用抗CGRP抗体或抑制畏光特别是CGRP相关畏光的抗体片段抑制或预防有需要的受试者的畏光的方法。 这些抗体和片段可用于治疗与畏光相关的不同疾病，例如偏头痛，丛集性头痛等。

公开(公告)号：US20120294822A1

公开(公告)日：2012-11-22

申请号：US13476104

申请日：2012-05-21

申请人： Andrew F. Russo ,  Eric A. Kaiser ,  Ana Recober ,  Adisa Kuburas ,  Ann C. Raddant ,  Brian Robert Kovacevich ,  John A. Latham ,  Jeffrey T.L. Smith ,  Leon F. Garcia-Martinez

发明人： Andrew F. Russo ,  Eric A. Kaiser ,  Ana Recober ,  Adisa Kuburas ,  Ann C. Raddant ,  Brian Robert Kovacevich ,  John A. Latham ,  Jeffrey T.L. Smith ,  Leon F. Garcia-Martinez

IPC分类号： A61K39/395 ,  A61P1/12 ,  A61K31/785

CPC分类号： A61K45/06 ,  A61K2039/505 ,  C07K16/26 ,  C07K2317/24 ,  C07K2317/76

摘要： The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular the methods prevent or reduce diarrhea in conditions or treatments resulting in elevated CGRP levels, e.g., in the GI tract (colon) that are associated with diarrhea and/or improper electrolyte and fluid excretion from the bowel or urinary system. More specifically, this invention relates to treatments using the anti-CGRP antibodies and fragments described herein, and binding fragments thereof.

摘要翻译： 本发明涉及通过给予对CGRP具有结合特异性的治疗或预防有效量的抗体及其片段来治疗慢性或急性形式的腹泻的方法。 特别地，所述方法防止或减轻导致CGRP水平升高的病症或治疗中的腹泻，例如与腹泻相关的胃肠道（结肠）和/或来自肠道或泌尿系统的不适当的电解质和流体排泄物。 更具体地，本发明涉及使用本文所述的抗CGRP抗体和片段的治疗及其结合片段。