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1.
公开(公告)号:US20110306517A1
公开(公告)日:2011-12-15
申请号:US13213390
申请日:2011-08-19
申请人: Andrew L. Feldman , Ahmet Dogan , George Vasmatzis , Mark Law , David I. Smith
发明人: Andrew L. Feldman , Ahmet Dogan , George Vasmatzis , Mark Law , David I. Smith
IPC分类号: C40B30/04 , C12Q1/42 , G01N33/573 , C12Q1/68
CPC分类号: A61K31/713 , G01N33/57407 , G01N2333/4703
摘要: This document relates to the activity of interferon regulatory factor 4 (IRF4) in T-cell lymphomas. For example, methods and materials involved in reducing the expression of an IRF4 polypeptide in T-cell lymphoma cells and identifying agents having the ability to reduce expression of an IRF4 polypeptide in T-cell lymphoma cells are provided. This document also relates to reducing DUSP22 or FLJ43663 polypeptide activity in T-cell lymphomas. For example, methods and materials involved in reducing the expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells and identifying agents having the ability to reduce expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells are provided.
摘要翻译: 本文件涉及干扰素调节因子4(IRF4)在T细胞淋巴瘤中的活性。 例如,提供了涉及减少T细胞淋巴瘤细胞中的IRF4多肽的表达的方法和材料,以及鉴定具有减少T细胞淋巴瘤细胞中的IRF4多肽表达的能力的试剂。 本文还涉及减少T细胞淋巴瘤中的DUSP22或FLJ43663多肽活性。 例如,提供涉及降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽的表达的方法和材料,以及具有降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽表达的能力的鉴定试剂 。
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2.
公开(公告)号:US08679743B2
公开(公告)日:2014-03-25
申请号:US13213390
申请日:2011-08-19
申请人: Andrew L. Feldman , Ahmet Dogan , George Vasmatzis , Mark Law , David I. Smith
发明人: Andrew L. Feldman , Ahmet Dogan , George Vasmatzis , Mark Law , David I. Smith
IPC分类号: C12Q1/68
CPC分类号: A61K31/713 , G01N33/57407 , G01N2333/4703
摘要: This document relates to the activity of interferon regulatory factor 4 (IRF4) in T-cell lymphomas. For example, methods and materials involved in reducing the expression of an IRF4 polypeptide in T-cell lymphoma cells and identifying agents having the ability to reduce expression of an IRF4 polypeptide in T-cell lymphoma cells are provided. This document also relates to reducing DUSP22 or FLJ43663 polypeptide activity in T-cell lymphomas. For example, methods and materials involved in reducing the expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells and identifying agents having the ability to reduce expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells are provided.
摘要翻译: 本文件涉及干扰素调节因子4(IRF4)在T细胞淋巴瘤中的活性。 例如,提供了涉及减少T细胞淋巴瘤细胞中的IRF4多肽的表达的方法和材料,以及鉴定具有减少T细胞淋巴瘤细胞中的IRF4多肽表达的能力的试剂。 本文还涉及减少T细胞淋巴瘤中的DUSP22或FLJ43663多肽活性。 例如,提供涉及降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽的表达的方法和材料,以及具有降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽表达的能力的鉴定试剂 。
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3.
公开(公告)号:US20100324119A1
公开(公告)日:2010-12-23
申请号:US12782484
申请日:2010-05-18
申请人: Andrew L. Feldman , Ahmet Dogan , George Vasmatzis , Mark Law , David I. Smith
发明人: Andrew L. Feldman , Ahmet Dogan , George Vasmatzis , Mark Law , David I. Smith
IPC分类号: A61K31/713 , C12Q1/68 , G01N33/68 , A61P35/00
CPC分类号: A61K31/713 , G01N33/57407 , G01N2333/4703
摘要: This document relates to the activity of interferon regulatory factor 4 (IRF4) in T-cell lymphomas. For example, methods and materials involved in reducing the expression of an IRF4 polypeptide in T-cell lymphoma cells and identifying agents having the ability to reduce expression of an IRF4 polypeptide in T-cell lymphoma cells are provided. This document also relates to reducing DUSP22 or FLJ43663 polypeptide activity in T-cell lymphomas. For example, methods and materials involved in reducing the expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells and identifying agents having the ability to reduce expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells are provided.
摘要翻译: 本文件涉及干扰素调节因子4(IRF4)在T细胞淋巴瘤中的活性。 例如,提供了涉及减少T细胞淋巴瘤细胞中的IRF4多肽的表达的方法和材料,以及鉴定具有减少T细胞淋巴瘤细胞中的IRF4多肽表达的能力的试剂。 本文还涉及减少T细胞淋巴瘤中的DUSP22或FLJ43663多肽活性。 例如,提供涉及降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽的表达的方法和材料,以及具有降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽表达的能力的鉴定试剂 。
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