公开(公告)号：US20240342302A1

公开(公告)日：2024-10-17

申请号：US18617021

申请日：2024-03-26

申请人： Angiex, Inc.

发明人： Paul A. Jaminet ,  Shou-Ching S. Jaminet ,  Edward H. Ha ,  Manish Hudlikar ,  Gabriel Gonzalez ,  Aaron Mallek

IPC分类号： A61K47/68 ,  A61K47/54 ,  A61K47/55

CPC分类号： A61K47/6849 ,  A61K47/545 ,  A61K47/55

摘要： Degrader-antibody conjugates (DACs) are described, comprising anti-TM4SF1 antibodies, and antigen-binding fragments thereof. Degrader molecules as described comprise a ubiquitin E3 ligase binding group (E3LB) and a protein binding group (PB). Linkers may be utilized between the antibodies and the degrader molecules (linker L1) and between the ubiquitin E3 ligase binding group (E3LB) and the protein binding group (PB) of the degrader molecule (linker L2). Methods of use of the DACs are also described.

公开(公告)号：US20240166759A1

公开(公告)日：2024-05-23

申请号：US18473511

申请日：2023-09-25

申请人： Angiex, Inc.

发明人： Paul A. Jaminet ,  Shou-Ching S. Jaminet ,  Gabriel Gonzalez

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61K39/00

CPC分类号： C07K16/2896 ,  A61K47/68031 ,  A61K47/68033 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/507 ,  C07K2317/565

摘要： Anti-TM4SF1 antibodies, and antigen-binding fragments thereof, are described and antibody drug conjugates containing the same, and combinations of such antibodies and ADCs with an immunotherapy, such as an immunomodulatory agent.