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公开(公告)号：US07507716B2
公开(公告)日：2009-03-24
申请号：US11482096
申请日：2006-07-06
IPC分类号： A61K38/16 , A61K38/00 , C07K14/435 , C07K14/00
CPC分类号： A61K38/17
摘要： The embodiments disclosed herein provide methods for inhibiting, reducing and/or treating pain in a subject by administering to a subject in need thereof a pharmaceutical formulation that includes a pharmacologically active compound that is adapted to disrupt PRL signaling in pain neurons. In certain embodiments, the compound is a PRL-R antagonist. In certain embodiments, the compound is adapted to alter the expression of one or more components involved in PRL signaling. Also provided for herein are methods to diagnose a pain disorder in a subject, comprising obtaining a measure of the amount of PRL or PRL mRNA in a biological sample.
摘要翻译： 本文公开的实施方案提供了通过向有需要的受试者施用药物制剂来抑制，减少和/或治疗受试者的疼痛的方法，药物制剂包括适于破坏疼痛神经元中的PRL信号传导的药理活性化合物。 在某些实施方案中，化合物是PRL-R拮抗剂。 在某些实施方案中，化合物适于改变参与PRL信号传导的一种或多种组分的表达。 本文还提供了诊断受试者疼痛障碍的方法，包括获得生物样品中PRL或PRL mRNA量的量度。
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公开(公告)号：US20070087966A1
公开(公告)日：2007-04-19
申请号：US11482096
申请日：2006-07-06
CPC分类号： A61K38/17
摘要： The embodiments disclosed herein provide methods for inhibiting, reducing and/or treating pain in a subject by administering to a subject in need thereof a pharmaceutical formulation that includes a pharmacologically active compound that is adapted to disrupt PRL signaling in pain neurons. In certain embodiments, the compound is a PRL-R antagonist. In certain embodiments, the compound is adapted to alter the expression of one or more components involved in PRL signaling. Also provided for herein are methods to diagnose a pain disorder in a subject, comprising obtaining a measure of the amount of PRL or PRL mRNA in a biological sample.
摘要翻译： 本文公开的实施方案提供了通过向有需要的受试者施用药物制剂来抑制，减少和/或治疗受试者的疼痛的方法，药物制剂包括适于破坏疼痛神经元中的PRL信号传导的药理活性化合物。 在某些实施方案中，化合物是PRL-R拮抗剂。 在某些实施方案中，化合物适于改变参与PRL信号传导的一种或多种组分的表达。 本文还提供了诊断受试者疼痛障碍的方法，包括获得生物样品中PRL或PRL mRNA量的量度。
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