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公开(公告)号：US07678816B2
公开(公告)日：2010-03-16
申请号：US10773535
申请日：2004-02-05
申请人： Claude Singer , Anita Liberman , Irena Veinberg
发明人： Claude Singer , Anita Liberman , Irena Veinberg
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D401/12
摘要： The present invention provides a stable 2-(2-pyridylmethyl)sulfinyl-1H-benzimidazole (lansoprazole) and a method for stabilizing lansoprazole by use of a weakly basic material. The present invention also provides a method for the preparation of a stable lansoprazole.
摘要翻译： 本发明提供稳定的2-（2-吡啶基甲基）亚磺酰基-1H-苯并咪唑（兰索拉唑）和通过使用弱碱性物质来稳定兰索拉唑的方法。 本发明还提供了制备稳定的兰索拉唑的方法。
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公开(公告)号：US07022859B2
公开(公告)日：2006-04-04
申请号：US11084269
申请日：2005-03-18
申请人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
发明人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present invention also provides a process for recrystallizing lansoprazole to obtain a lansoprazole containing less than about 0.1% (wt/wt) water.
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公开(公告)号：US20050165059A1
公开(公告)日：2005-07-28
申请号：US11083485
申请日：2005-03-18
申请人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
发明人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
IPC分类号： C07D401/12 , C07D43/02 , A61K31/4439
CPC分类号： C07D401/12
摘要： The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present invention also provides a process for recrystallizing lansoprazole to obtain a lansoprazole containing less than about 0.1% (wt/wt) water.
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4.发明授权Stable iansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol 失效含有超过500ppm，高达约3,000ppm水和超过200ppm，高达约5,000ppm酒精的稳定的索非唑公开(公告)号：US07683080B2
公开(公告)日：2010-03-23
申请号：US10717325
申请日：2003-11-18
申请人： Anita Liberman , Claude Singer , Irena Veinberg
发明人： Anita Liberman , Claude Singer , Irena Veinberg
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D401/12
摘要： The present invention provides a stable 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazole (lansoprazole) comprising either greater than 500 ppm and not more than about 3,000 ppm water or greater than 200 ppm and not more than about 5,000 ppm alcohol, or both. The present invention provides a method of preparing a stable lansoprozole as well as a pharmaceutical composition containing same. The present invention further provides a method of purifying lansoprazole that is substantially free of sulfone and sulfide derivatives.
摘要翻译： 本发明提供包含大于500ppm且不大于约3,000ppm水或大于200ppm且不超过约5,000ppm的醇的稳定的2-（2-吡啶基甲基）亚磺酰基-1H-苯并咪唑（兰索拉唑），或 都。 本发明提供了制备稳定的兰索佐唑以及含有它的药物组合物的方法。 本发明还提供了一种纯化基本上不含砜和硫化物衍生物的兰索拉唑的方法。
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公开(公告)号：US20050165060A1
公开(公告)日：2005-07-28
申请号：US11083652
申请日：2005-03-18
申请人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
发明人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
IPC分类号： C07D401/12 , C07D43/02 , A61K31/4439
CPC分类号： C07D401/12
摘要： The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present invention also provides a process for recrystallizing lansoprazole to obtain a lansoprazole containing less than about 0.1% (wt/wt) water.
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公开(公告)号：US20050020638A1
公开(公告)日：2005-01-27
申请号：US10773535
申请日：2004-02-05
申请人： Claude Singer , Anita Liberman , Irena Veinberg
发明人： Claude Singer , Anita Liberman , Irena Veinberg
IPC分类号： A61K31/4439 , A61P1/04 , C07D401/12 , C07
CPC分类号： C07D401/12
摘要： The present invention provides a stable 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazole (lansoprazole) and a method for stabilizing lansoprazole by use of a weakly basic material. The present invention also provides a method for the preparation of a stable lansoprazole.
摘要翻译： 本发明提供稳定的2-（2-吡啶基甲基）亚磺酰基-1H-苯并咪唑（兰索拉唑）和通过使用弱碱性物质来稳定兰索拉唑的方法。 本发明还提供了制备稳定的兰索拉唑的方法。
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公开(公告)号：US07622588B2
公开(公告)日：2009-11-24
申请号：US11083485
申请日：2005-03-18
申请人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
发明人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present invention also provides a process for recrystallizing lansoprazole to obtain a lansoprazole containing less than about 0.1% (wt/wt) water.
摘要翻译： 本发明提供一种制备基本上纯的兰索拉唑的方法，该兰索拉唑含有少于约0.2％（重量/重量）的杂质，包括砜/硫化物衍生物。 本发明还提供了使兰索拉唑重结晶以获得含有少于约0.1％（wt / wt）水的兰索拉唑的方法。
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公开(公告)号：US20050165061A1
公开(公告)日：2005-07-28
申请号：US11084269
申请日：2005-03-18
申请人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
发明人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
IPC分类号： C07D401/12 , A61K31/4439 , C07D43/02
CPC分类号： C07D401/12
摘要： The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present invention also provides a process for recrystallizing lansoprazole to obtain a lansoprazole containing less than about 0.1% (wt/wt) water.
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公开(公告)号：US07060837B2
公开(公告)日：2006-06-13
申请号：US11083652
申请日：2005-03-18
申请人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
发明人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present invention also provides a process for recrystallizing lansoprazole to obtain a lansoprazole containing less than about 0.1% (wt/wt) water.
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公开(公告)号：US06909004B2
公开(公告)日：2005-06-21
申请号：US10646059
申请日：2003-08-21
申请人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
发明人： Claude Singer , Anita Liberman , Irena Veinberg , Nina Finkelstein , Tamar Nidam
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present invention also provides a process for recrystallizing lansoprazole to obtain a lansoprazole containing less than about 0.1% (wt/wt) water.
摘要翻译： 本发明提供一种制备基本上纯的兰索拉唑的方法，该兰索拉唑含有少于约0.2％（重量/重量）的杂质，包括砜/硫化物衍生物。 本发明还提供了使兰索拉唑重结晶以获得含有少于约0.1％（wt / wt）水的兰索拉唑的方法。
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