公开(公告)号：US6130205A

公开(公告)日：2000-10-10

申请号：US470045

申请日：1995-06-06

申请人： Ann Stapleton ,  Edward Nudelman ,  Sen-itiroh Hakomori ,  Walter E. Stamm ,  Mark Stroud

发明人： Ann Stapleton ,  Edward Nudelman ,  Sen-itiroh Hakomori ,  Walter E. Stamm ,  Mark Stroud

IPC分类号： A61K31/7028 ,  G01N33/50 ,  G01N33/66 ,  A61K31/70

CPC分类号： A61K31/7028 ,  G01N33/5091 ,  G01N33/66 ,  Y10S435/96

摘要： A method for determining susceptibility to E. coli urinary tract infection comprising assaying a sample of epithelial cells for the presence or absence of at least one of Le.sup.a, sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and an extended globo structure carrying the same terminal epitopes as Le.sup.a, sialosyl galactosyl-globoside or disialosyl galactosyl-globoside or assaying a sample of vaginal secretions for the presence or absence of at least one of sialosyl galactosyl-globoside or disialosyl galactosyl-globoside, and detecting the presence or absence of the at least one of Le.sup.a, sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and the extended globo structure, as well as a method for diagnosing secretors and nonsecretors of histo-blood group antigens comprising assaying a sample of vaginal epithelial cells, vaginal secretions or buccal epithelial cells for the presence or absence of at least one of sialosyl galactosyl-globoside and disialosyl galactosyl-globoside, and detecting the presence or absence of the at least one of sialosyl galactosyl-globoside and disialosyl galactosyl-globoside, and a method for diagnosing secretors of histo-blood group antigens comprising assaying a sample of vaginal epithelial cells or vaginal secretions for the presence or absence of at least one of globo H, globo ABO and lacto ABO, and detecting for the presence or absence of the at least one of globo H, globo ABO and lacto ABO and, further, a medicament comprising a biologically effective amount of at least one E. coli bacterial receptor analogue, and a pharmaceutically acceptable diluent, carrier or excipient as well as a method for preventing E. coli urinary tract infection comprising administering to a host a biologically effective amount of at least one E. coli bacterial receptor or bacterial receptor analogue.

公开(公告)号：US5374532A

公开(公告)日：1994-12-20

申请号：US936400

申请日：1992-08-31

申请人： Ann Stapleton ,  Edward Nudelman ,  Sen-itiroh Hakomori ,  Walter E. Stamm

发明人： Ann Stapleton ,  Edward Nudelman ,  Sen-itiroh Hakomori ,  Walter E. Stamm

IPC分类号： A61K31/7028 ,  G01N33/50 ,  G01N33/66 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569

CPC分类号： A61K31/7028 ,  G01N33/5091 ,  G01N33/66 ,  Y10S435/96

摘要： A method for determining susceptibility to E. coli urinary tract infection comprising assaying a sample of epithelial cells for the presence or absence of at least one of sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and an extended globo structure carrying the same terminal epitopes as sialosyl galactosyl-globoside or disialosyl galactosyl-globoside, or assaying a sample of vaginal secretions for the presence or absence of at least one of sialosyl galactosyl-globoside or disialosyl galactosyl-globoside, and detecting the presence or absence of the at least one of sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and the extended globo structure, a medicament comprising a biologically effective amount of at least one E. coli bacterial receptor analogue and a pharmaceutically acceptable diluent, carrier or excipient as well as a method for preventing E. coli urinary tract infection comprising administering to a host a biologically effective amount of at least one E. coli bacterial receptor or bacterial receptor analogue are disclosed.

摘要翻译： 用于测定对大肠杆菌尿道感染的敏感性的方法，包括测定上皮细胞样品中是否存在唾液糖基半乳糖基 - 球苷，唾液酸半乳糖基 - 球形蛋白和延伸的具有与唾液酸基相同的末端表位的延伸的球形结构 半乳糖基 - 球苷或二唾液酸半乳糖基 - 球苷，或测定阴道分泌物样品中是否存在至少一种唾液糖基半乳糖苷 - 甙基或二唾液酸半乳糖苷 - 球苷，并检测唾液糖基半乳糖基 - 甙基中至少一种的存在或不存在 珠糖苷，二唾液酸半乳糖苷 - 球蛋白和延长的球形结构，包含生物有效量的至少一种大肠杆菌细菌受体类似物和药学上可接受的稀释剂，载体或赋形剂的药物以及预防大肠杆菌尿 道感染包括向宿主施用生物有效量的lea 公开了第一大肠杆菌细菌受体或细菌受体类似物。

公开(公告)号：US06432681B1

公开(公告)日：2002-08-13

申请号：US09350374

申请日：1999-07-09

申请人： Ann Stapleton ,  Edward Nudelman ,  Walter E. Stamm ,  Sen-Itiroh Hakomori

发明人： Ann Stapleton ,  Edward Nudelman ,  Walter E. Stamm ,  Sen-Itiroh Hakomori

IPC分类号： C12P1900

CPC分类号： A61K31/7028 ,  G01N33/5091 ,  G01N33/66 ,  Y02A50/473

摘要： Compositions and methods for diagnosing, treating and preventing recurrent E. coli urinary tract infections relate to the detection and use of globosides, such as disialosyl galactosyl-globoside (DSGG) and sialosyl galactosyl-globoside (SGG), and stabilized forms thereof, such as those wherein sialic acid is replaced by KDN

摘要翻译： 用于诊断，治疗和预防复发性大肠杆菌尿路感染的组合物和方法涉及检测和使用球状体，例如二唾液酸半乳糖苷 - 球苷（DSGG）和唾液酸半乳糖苷 - 球蛋白（SGG）及其稳定形式，例如 唾液酸被KDN代替的那些