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公开(公告)号：US07999096B2
公开(公告)日：2011-08-16
申请号：US12086242
申请日：2006-12-12
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/3231
摘要： The present invention relates to novel isolated siRNAs comprising a sense RNA strand and a complementary antisense RNA strand which together form an RNA duplex, characterized in that the sense RNA strand comprises a sequence which has at most one nucleotide that is distinct in relation to a fragment of 14 to 30 contiguous nucleotides of the nucleotide sequence of exon F of the gene encoding the myosin Va protein, and also to compositions comprising at least one such siRNA, and to the use of at least one such siRNA as a cosmetic or therapeutic agent for skin depigmentation.
摘要翻译： 本发明涉及包含一起形成RNA双链体的正义RNA链和互补反义RNA链的新型分离的siRNA，其特征在于有义RNA链包含至少一个与片段不同的核苷酸的序列 编码肌球蛋白Va蛋白的基因的外显子F的核苷酸序列的14至30个连续核苷酸，以及包含至少一种这样的siRNA的组合物，以及使用至少一种这样的siRNA作为化妆品或治疗剂 皮肤色素沉着
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公开(公告)号：US20090239934A1
公开(公告)日：2009-09-24
申请号：US12086242
申请日：2006-12-12
IPC分类号： A61K31/7088 , C07H21/02
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/3231
摘要： The present invention relates to novel isolated siRNAs comprising a sense RNA strand and a complementary antisense RNA strand which together form an RNA duplex, characterized in that the sense RNA strand comprises a sequence which has at most one nucleotide that is distinct in relation to a fragment of 14 to 30 contiguous nucleotides of the nucleotide sequence of exon F of the gene encoding the myosin Va protein, and also to compositions comprising at least one such siRNA, and to the use of at least one such siRNA as a cosmetic or therapeutic agent for skin depigmentation.
摘要翻译： 本发明涉及包含一起形成RNA双链体的正义RNA链和互补反义RNA链的新型分离的siRNA，其特征在于有义RNA链包含至少一个与片段不同的核苷酸的序列 编码肌球蛋白Va蛋白的基因的外显子F的核苷酸序列的14至30个连续核苷酸，以及包含至少一种这样的siRNA的组合物，以及使用至少一种这样的siRNA作为化妆品或治疗剂 皮肤色素沉着
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