公开(公告)号：US06492382B1

公开(公告)日：2002-12-10

申请号：US09423200

申请日：1999-11-03

申请人： Annika Björe ,  Anna-Karin Granath

发明人： Annika Björe ,  Anna-Karin Granath

IPC分类号： A61K31439

CPC分类号： C07D471/08 ,  A61K9/19 ,  A61K31/439 ,  Y10S514/821

摘要： The present invention relates to dried preparations containing a class III antiarrhythmic compound in the form of a crystalline or amorphous salt or any combination thereof, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. The present invention also relates to frozen preparations containing a class III antiarrhythmic compound in the form of a salt solution, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. Preferred preparations contain a salt of the compound 3,7-diazabicyclo[3.3.1]-nonane-3-carboxylic acid, 7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-1,1-dimethylethyl ester (Compound A). Further aspects of the present invention include salts of Compound A per se, processes for preparing the preparations, as well as use of the preparations for prophylaxis and/or treatment of cardiac arrhytmia.

摘要翻译： 本发明涉及含有结晶或无定形盐或其任何组合形式的III类抗心律失常化合物的干燥制剂，其中抗衡离子选自药学上可接受的水溶性有机酸或无机酸。 本发明还涉及含有盐溶液形式的III类抗心律失常化合物的冷冻制剂，其中抗衡离子选自药学上可接受的水溶性有机酸或无机酸。 优选的制剂含有化合物3,7-二氮杂双环[3.3.1] - 壬烷-3-羧酸，7 - [（2S）-3-（4-氰基苯氧基）-2-羟丙基] 二甲基乙基酯（化合物A）。 本发明的其它方面包括化合物A本身的盐，制备方法，以及用于预防和/或治疗心脏性心律的制剂。